Shinji Shimoda, Kenichi Harada, Hiroaki Niiro, Tomoharu Yoshizumi, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara, Koichi Tsuneyama, Minoru Nakamura, Atsumasa Komori, Kiyoshi Migita, Yasuni Nakanuma, Hiromi Ishibashi, Carlo Selmi, M. Eric Gershwin – 26 February 2008 – Primary biliary cirrhosis (PBC) is characterized by the highly selective autoimmune injury of small intrahepatic bile ducts, despite widespread distribution of mitochondrial autoantigens.

Zhenyuan Song, Zhanxiang Zhou, Ion Deaciuc, Theresa Chen, Craig J. McClain – 26 February 2008 – Although recent evidence suggests that down‐regulation of production of the adipocyte hormone adiponectin has pathophysiological consequences for the development of alcoholic liver disease (ALD), the underlying mechanisms are elusive. Abnormal hepatic methionine‐homocysteine metabolism induced by prolonged alcohol exposure has been reported both in clinical and experimental studies of ALD.

Johannes Herkel, Ansgar W. Lohse – 26 February 2008

Naoshi Nishida, Takeshi Nagasaka, Takafumi Nishimura, Iwao Ikai, C. Richard Boland, Ajay Goel – 26 February 2008 – Aberrant DNA methylation is an important epigenetic alteration in hepatocellular carcinoma (HCC). However, the molecular processes underlying the methylator phenotype and the contribution of hepatitis viruses are poorly understood. The current study is a comprehensive methylation analysis of human liver tissue specimens. A total of 176 liver tissues, including 77 pairs of HCCs and matching noncancerous liver and 22 normal livers, were analyzed for methylation.

Zachary D. Goodman, Hala R. Makhlouf, Lea Liu, William Balistreri, Regino P. Gonzalez‐Peralta, Barbara Haber, Maureen M. Jonas, Parvathi Mohan, Jean P. Molleston, Karen F. Murray, Michael R. Narkewicz, Philip Rosenthal, Lesley J. Smith, Patricia R. Robuck, Kathleen B. Schwarz – 26 February 2008 – There is relatively little information in the literature on the histopathology of chronic hepatitis C in children.

Rupert Abdalian, Preeti Dhar, Kartik Jhaveri, Masoom Haider, Maha Guindi, E. Jenny Heathcote – 26 February 2008 – Large bile duct injury (that seen on cholangiography) is not usually considered a feature of autoimmune hepatitis (AIH) in adults but is present in up to 50% of children with AIH. The aim of this work was to study the prevalence of large bile duct abnormalities identified by magnetic resonance cholangiography (MRC) in adults given a diagnosis of AIH.

Irwin M. Arias – 26 February 2008

Terry G. J. Derks, Theo H. van Dijk, Aldo Grefhorst, Jan‐Peter Rake, G. Peter A. Smit, Folkert Kuipers, Dirk‐Jan Reijngoud – 26 February 2008 – Mitochondrial fatty acid oxidation (mFAO) is considered to be essential for driving gluconeogenesis (GNG) during fasting. However, quantitative in vivo data on de novo synthesis of glucose‐6‐phosphate upon acute inhibition of mFAO are lacking.

Defeng Wu, Arthur Cederbaum – 26 February 2008 – The goal of this study was to evaluate the role of mitogen‐activated protein kinase (MAPK) in cytochrome P4502E1 (CYP2E1) potentiation of lipopolysaccharide or tumor necrosis factor alpha (TNF‐α)–induced liver injury. Treatment of C57/BL/6 mice with pyrazole (PY) plus lipopolysaccharide (LPS) induced liver injury compared with mice treated with PY or LPS alone. The c‐Jun N‐terminal kinase (JNK) inhibitor SP600125 or p38 MAPK inhibitor SB203580 prevented this liver injury.

26 February 2008