An intention‐to‐treat analysis of liver transplantation for hepatocellular carcinoma using organ procurement transplant network data

Shawn J. Pelletier, Sherry Fu, Veena Thyagarajan, Carlos Romero‐Marrero, Mashal J. Batheja, Jeffrey D. Punch, John C. Magee, Anna S. Lok, Robert J. Fontana, Jorge A. Marrero – 29 July 2009 – Single‐center studies have shown acceptable long‐term outcomes following orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) when tumors are within the Milan criteria. However, the overall survival and waiting list removal rates have not been described at a national level with pooled registry data.

Sustained virological response to interferon plus ribavirin reduces liver‐related complications and mortality in patients coinfected with human immunodeficiency virus and hepatitis C virus

Juan Berenguer, Julio Álvarez‐Pellicer, Pilar Miralles Martín, José López‐Aldeguer, Miguel Angel Von‐Wichmann, Carmen Quereda, Josep Mallolas, José Sanz, Cristina Tural, José María Bellón, Juan González‐García, The GESIDA3603/5607 Study Group – 29 July 2009 – Human immunodeficiency virus (HIV) infection modifies the natural history of chronic hepatitis C, thus promoting more rapid progression to cirrhosis and end‐stage liver disease.

Prognostic value of computerized quantification of liver fibrosis in children with biliary atresia

Lars Pape, Karen Olsson, Claus Petersen, Reinhard von Wasilewski, Michael Melter – 29 July 2009 – Biliary atresia (BA) is the leading indication for liver transplantation (LTx) during childhood. Predictive markers for progression are lacking. We investigated the correlation between quantified fibrosis of the liver at the time of Kasai hepatic portoenterostomy (KPE) and the clinical course. Liver tissue was obtained at the time of KPE in 53 children and stained with Picrosirius red. The mean volume of fibrosis per number of periportal fields (Vfib) and the Ishak score were calculated.

Late protocol liver biopsies in the liver allograft: A neglected investigation?

George Mells, Caroline Mann, Stefan Hubscher, James Neuberger – 29 July 2009 – As outcomes from liver transplantation have improved, attention has focused on long‐term outcomes: patient and graft survival is affected by many factors, including the consequences of both overimmunosuppression (eg, renal failure and cancer) and underimmunosuppression (eg, rejection). The use of protocol (rather than event‐driven) biopsies of the liver allograft, except for those grafted for HCV infection, has been largely abandoned.

Effect of alcoholic liver disease and hepatitis C infection on waiting list and posttransplant mortality and transplant survival benefit

Michael R. Lucey, Douglas E. Schaubel, Mary K. Guidinger, Santiago Tome, Robert M. Merion – 29 July 2009 – Disease‐specific analysis of liver transplant survival benefit, which encompasses both pre‐ and posttransplant events, has not been reported.

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