Youmin Wu, Frederick C. Johlin, Stephen C. Rayhill, Chris S. Jensen, Jin Xie, Michael B. Cohen, Frank A. Mitros – 27 February 2008 – This retrospective study reviews our experience in surveillance and early detection of cholangiocarcinoma (CC) and in using en bloc total hepatectomy–pancreaticoduodenectomy–orthotopic liver transplantation (OLT‐Whipple) to achieve complete eradication of early‐stage CC complicating primary sclerosing cholangitis (PSC).

J. Ignacio Herrero, Bruno Sangro, Fernando Pardo, Jorge Quiroga, Mercedes Iñarrairaegui, Fernando Rotellar, Custodia Montiel, Felix Alegre, Jesus Prieto – 27 February 2008 – Milan criteria are the most frequently used limits for liver transplantation (LT) in patients with hepatocellular carcinoma (HCC), but our previous experience with expanded criteria showed encouraging results. The aim of this study was to investigate whether our expanded Clinica Universitaria de Navarra (CUN) criteria (1 nodule up to 6 cm or 2–3 nodules up to 5 cm each) could be used to select patients with HCC for LT.

Federico Aucejo, Zuhaib Ibrahim, Koji Hashimoto, Cristiano Quintini, Dympna Kelly, David Vogt, Bijan Eghtesad, John Fung, Charles Miller, Ralph Tuthill – 27 February 2008 – Some chromosomal alterations can be associated with vascular abnormalities. For instance, Turner syndrome can be complicated by agenesis or hypoplasia of the portal venous system causing presinusoidal portal hypertension. Liver transplantation to treat this condition overcomes portal hypertension and reconstitutes the diminished hepatic function due to severe atrophy of the portal venous inflow.

Daryl T.‐Y. Lau, Penny Mar Fish, Mala Sinha, David M. Owen, Stanley M. Lemon, Michael Gale – 26 February 2008 – Interferon regulatory factor‐3 (IRF‐3) activation directs α/β interferon production and interferon‐stimulated gene (ISG) expression, which limits virus infection.

Tae Hoon Lee, W. Ray Kim, Joanne T. Benson, Terry M. Therneau, L. Joseph Melton – 26 February 2008 – Serum aminotransferase [such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] is commonly used as an indicator of liver disease. The aim of the study was to determine the degree to which aminotransferase results are associated with increased mortality at the population level.

Manuel Romero‐Gómez, Emilio Gómez‐González, Ana Madrazo, Marina Vera‐Valencia, Luis Rodrigo, Ramón Pérez‐Alvarez, Rosa Pérez‐López, Victor M. Castellano‐Megias, Manuel Nevado‐Santos, Juan C. Alcón, Ricard Solá, José M. Pérez‐Moreno, José M. Navarro, Raúl J. Andrade, Javier Salmerón, Manuel Fernández‐López, Rafael Aznar, Moisés Diago – 26 February 2008 – This study was undertaken to evaluate an image processing method for assessing liver fibrosis in conventional computed tomography (CT) scans in patients with chronic hepatitis C.

Anne Myara, Jérôme Guechot, Elisabeth Lasnier, Françoise Imbert‐Bismut, Hélène Voitot, Georges Ferard – 26 February 2008

Elizabeth M. Brunt – 26 February 2008

26 February 2008

Defeng Wu, Arthur Cederbaum – 26 February 2008 – The goal of this study was to evaluate the role of mitogen‐activated protein kinase (MAPK) in cytochrome P4502E1 (CYP2E1) potentiation of lipopolysaccharide or tumor necrosis factor alpha (TNF‐α)–induced liver injury. Treatment of C57/BL/6 mice with pyrazole (PY) plus lipopolysaccharide (LPS) induced liver injury compared with mice treated with PY or LPS alone. The c‐Jun N‐terminal kinase (JNK) inhibitor SP600125 or p38 MAPK inhibitor SB203580 prevented this liver injury.