Liver transplantation for hepatoblastoma

Walid Faraj, Faisal Dar, Gabriele Marangoni, Adam Bartlett, Hector Vilca Melendez, Dino Hadzic, Anil Dhawan, Georgina Mieli‐Vergani, Mohamed Rela, Nigel Heaton – 29 October 2008 – From October 1993 to February 2007, 25 liver transplantations were performed for hepatoblastoma. Of these 25, 18 children received cadaveric grafts, and 7 received left lateral segments from living donors.

Failure to fully disclose during pretransplant psychological evaluation in alcoholic liver disease: A driving under the influence corroboration study

Jasmohan S. Bajaj, Kia Saeian, Muhammad Hafeezullah, Jose Franco, Andrea Thompson, Rebecca Anderson – 29 October 2008 – The prevention of recidivism in alcoholic liver disease is one of the aims of pretransplant psychological evaluation (PE). Failure to fully disclose the extent of alcohol use is evidence of ongoing alcoholism. Driving under the influence (DUI) represents objective evidence of alcohol abuse, but verifying DUIs through official records is not standard during PE.

Dynamic metabonomic analysis of BALB/C mice with different outcomes after D‐galactosamine/lipopolysaccharide–induced fulminant hepatic failure

Bo Feng, Shengming Wu, Sa Lv, Junjian Fang, Feng Liu, Yu Li, Yan Gao, Xianzhong Yan, Fangting Dong, Lai Wei – 29 October 2008 – Fulminant hepatic failure (FHF) is one of the most challenging gastrointestinal emergencies encountered in clinical practice. Early identification of patients with FHF who need liver transplantation is very important. To construct a prediction model for the early diagnosis and prognosis of FHF, we studied the dynamics of metabolic intermediates and metabolic profiles with a D‐galactosamine (GalN)/lipopolysaccharide (LPS)–treated BALB/c mouse model of FHF.

Reduced glutathione in the liver as a potential viability marker in non–heart‐beating donors

Markus Golling, Heidi Kellner, Hamidreza Fonouni, Morva Tahmasbi Rad, Renate Urbaschek, Raoul Breitkreutz, Martha Maria Gebhard, Arianeb Mehrabi – 29 October 2008 – Although the use of non–heart‐beating donors (NHBD) is the oldest type of organ transplantation, the results were and still are disappointing. To consider using a liver from NHBD, it is of importance to assess the graft viability. Our aim was to assess the role of reduced liver glutathione (rGSHL) as a potential predictive marker of liver function before transplantation.

Liver transplantation and subsequent risk of cancer: Findings from a Canadian cohort study

Ying Jiang, Paul J. Villeneuve, Stanley S. A. Fenton, Douglas E. Schaubel, Les Lilly, Yang Mao – 29 October 2008 – Characterization of the long‐term cancer risks among liver transplant patients has been hampered by the paucity of sufficiently large cohorts. The increase over time in the number of liver transplants coupled with improved survival underscores the need to better understand associated long‐term health effects. This is a cohort study whose subjects were assembled with data from the population‐based Canadian Organ Replacement Registry.

Paralysis in the left phrenic nerve after living‐donor liver transplantation for biliary atresia with situs inversus

Yukihiro Sanada, Koichi Mizuta, Youichi Kawano, Satoshi Egami, Makoto Hayashida, Shuji Hishikawa, Hideo Kawarasaki – 29 October 2008 – A 7‐month‐old boy with biliary atresia accompanied by situs inversus and absent inferior vena cava (IVC) underwent living‐donor liver transplantation (LDLT). Because a constriction in the recipient hepatic vein (HV) was detected during the preparation of the HV in LDLT, a dissection in the cranial direction and a total clamp of the suprahepatic IVC was performed, and the suprahepatic IVC and the graft HV were anastomosed end‐to‐end.

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