Aymin Delgado‐Borrego, Yun‐Sheen Liu, Sergio H. Jordan, Saurabh Agrawal, Hui Zhang, Marielle Christofi, Deborah Casson, A. Benedict Cosimi, Raymond T. Chung – 30 January 2008 – An association between hepatitis C virus (HCV) infection and insulin resistance (IR) has been recently reported. However, causality has not been established. The cross‐sectional nature of most reported studies and varying degrees of fibrosis have limited definitive conclusions about the independent role of HCV in development of IR.

Mina Komuta, Bart Spee, Sara Vander Borght, Rita De Vos, Chris Verslype, Raymond Aerts, Hirohisa Yano, Tetsuya Suzuki, Masanori Matsuda, Hideki Fujii, Valeer J. Desmet, Masamichi Kojiro, Tania Roskams – 29 January 2008 – Cholangiolocellular carcinoma (CLC), a subtype of cholangiocellular carcinoma (CC), is thought to originate from the ductules/canals of Hering, where hepatic progenitor cells (HPCs) are located. We investigated the clinicopathological features of 30 CLCs and their relationship to HPCs.

Sanaa M. Kamal, Imad A. Nasser – 28 January 2008 – Hepatitis C virus genotype 4 (HCV‐4) is the most common variant of the hepatitis C virus (HCV) in the Middle East and Africa, particularly Egypt. This region has the highest prevelance of HCV worldwide, with more than 90% of infections due to genotype 4. HCV‐4 has recently spread in several Western countries, particularly in Europe, due to variations in population structure, immigration, and routes of transmission. The features of HCV‐4 infection and the appropriate therapeutic regimen have not been well characterized.

Dechun Feng, Feng Zhou, Chuanfeng Wu – 26 January 2008

Ian Homer Y. Cua, Jacob George – 26 January 2008

Gary M. Reynolds, Helen J. Harris, Adam Jennings, Ke Hu, Joe Grove, Patricia F. Lalor, David H. Adams, Peter Balfe, Stefan G. Hübscher, Jane A. McKeating – 26 January 2008 – The principal site of hepatitis C virus (HCV) replication is the liver. HCV pseudoparticles infect human liver derived cell lines and this suggests that liver‐specific receptors contribute to defining HCV hepatotropism.

Edward B. Alabraba, Vincent Lai, Louis Boon, Stephen J. Wigmore, David H. Adams, Simon C. Afford – 26 January 2008 – In the vanishing bile duct syndromes (VBDS), primary biliary cirrhosis and chronic allograft rejection, cholangiocyte apoptosis is associated with sustained macrophage infiltration of the liver, suggesting that these cells may mediate tissue damage and contribute to bile duct destruction. We have previously reported that activation of CD40 on cholangiocytes with either soluble CD154 or cross‐linking monoclonal antibody to CD40 induces apoptosis in vitro.

Jean‐Charles Duclos‐Vallée, Cyrille Féray, Mylène Sebagh, Elina Teicher, Anne‐Marie Roque‐Afonso, Bruno Roche, Daniel Azoulay, René Adam, Henri Bismuth, Denis Castaing, Daniel Vittecoq, Didier Samuel, THEVIC Study Group – 26 January 2008 – Liver transplantation in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is a recent indication. In a single center, we have compared the survival and severity of recurrent HCV infection after liver transplantation in HIV‐HCV–coinfected and HCV‐monoinfected patients.

Michael Charlton, Paul Angulo, Naga Chalasani, Ralph Merriman, Kimberly Viker, Phunchai Charatcharoenwitthaya, Schuyler Sanderson, Samer Gawrieh, Anuradha Krishnan, Keith Lindor – 26 January 2008 – The biological basis of variability in histological progression of nonalcoholic fatty liver disease (NAFLD) is unknown. Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone and has been shown to influence sensitivity to oxidative stress, insulin sensitivity, and expression of peroxisome proliferator‐activated receptor alpha and procollagen messenger RNA.

Mladen I. Yovchev, Petar N. Grozdanov, Hongchao Zhou, Harini Racherla, Chandan Guha, Mariana D. Dabeva – 26 January 2008 – Oval cells appear and expand in the liver when hepatocyte proliferation is compromised. Many different markers have been attributed to these cells, but their nature still remains obscure. This study is a detailed gene expression analysis aimed at revealing their identity and repopulating in vivo capacity. Oval cells were activated in 2‐acetylaminofluorene–treated rats subjected to partial hepatectomy or in D‐galactosamine–treated rats.