Potential immunological advantage of intravenous mycophenolate mofetil with tacrolimus and steroids in primary deceased donor liver transplantation and live donor liver transplantation without antibody induction

Ashokkumar Jain, Rajeev Sharma, Charlotte Ryan, Georgious Tsoulfas, Mark Orloff, Peter Abt, Randeep Kashyap, Pam Batzold, Lisa Sauberman, Saman Safadjou, Maureen Graham, Adel Bozorgzadeh – 30 January 2008 – With the current immunosuppressive regimens, graft loss secondary to immunological reasons after successful liver transplantation is a rarity; acute rejections, however, do occur, with the majority of them being steroid‐responsive.

Risk factors for recurrence of primary sclerosing cholangitis after liver transplantation

Jacob Alexander, James D. Lord, Matthew M. Yeh, Carlos Cuevas, Ramasamy Bakthavatsalam, Kris V. Kowdley – 30 January 2008 – Orthotopic liver transplantation (OLT) is the only effective treatment for end‐stage liver disease due to primary sclerosing cholangitis (PSC). Recurrence of PSC has recently emerged as a leading cause of allograft failure in the long term. There is limited data on risk factors for recurrence of PSC. We performed a retrospective analysis of 69 consecutive patients who underwent a first OLT for PSC over a 14‐year period.

The effect of liver transplantation on autonomic dysfunction in patients with end‐stage liver disease

Elizabeth J. Carey, Manjushree Gautam, Timothy Ingall, David D. Douglas – 30 January 2008 – Autonomic dysfunction is a recognized complication of end‐stage liver disease (ESLD), but there is little information on how liver transplantation (LT) affects this problem. We sought to prospectively evaluate autonomic function in patients with ESLD before and after LT. Autonomic reflex screen (ARS) was performed on 30 patients with ESLD prior to transplantation. A 10‐point composite autonomic score (CAS) was calculated from these data.

Polyarteritis nodosa, presenting as life‐threatening gastrointestinal hemorrhage in a liver transplant recipient

Sheldon C. Cooper, Simon P. Olliff, Ian McCafferty, Stephen J. Wigmore, Darius F. Mirza – 30 January 2008 – This unique case reports the first recorded episode in the medical literature of vasculitis post‐liver transplantation, presenting as life‐threatening gastrointestinal hemorrhage. A 52‐year‐old Caucasian woman underwent orthotopic liver transplantation (OLT) for autoimmune cirrhosis complicated by hepatoma and portal vein thrombosis. Late hepatic artery thrombosis led to a second liver graft.

Eighteen years of liver transplantation experience in patients with advanced Budd‐Chiari syndrome

Frank Ulrich, Johann Pratschke, Ulf Neumann, Andreas Pascher, Gero Puhl, Peter Fellmer, Sascha Weiss, Sven Jonas, Peter Neuhaus – 30 January 2008 – The long‐term results of liver transplantation for Budd‐Chiari syndrome (BCS) and timely indication for the procedure are still under debate. Innovations in interventional therapy and better understanding of underlying diseases have improved therapy strategies. The aim of this study was the analysis of patient and disease characteristics, outcome, and specific complications.

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