Outcome of living donor liver transplantation for post‐Kasai biliary atresia in adults

Yusuke Kyoden, Sumihito Tamura, Yasuhiko Sugawara, Noriyo Yamashiki, Yuichi Matsui, Junichi Togashi, Junichi Kaneko, Norihiro Kokudo, Masatoshi Makuuchi – 30 January 2008 – Previous reports described the effectiveness of living donor liver transplantation (LDLT) for post‐Kasai biliary atresia (BA) in the pediatric population. Information on the outcome of LDLT in patients that have reached adulthood after the Kasai procedure, however, is limited. A recent report postulated a poorer long‐term outcome of LDLT in these adults.

Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin

Mina Komuta, Bart Spee, Sara Vander Borght, Rita De Vos, Chris Verslype, Raymond Aerts, Hirohisa Yano, Tetsuya Suzuki, Masanori Matsuda, Hideki Fujii, Valeer J. Desmet, Masamichi Kojiro, Tania Roskams – 29 January 2008 – Cholangiolocellular carcinoma (CLC), a subtype of cholangiocellular carcinoma (CC), is thought to originate from the ductules/canals of Hering, where hepatic progenitor cells (HPCs) are located. We investigated the clinicopathological features of 30 CLCs and their relationship to HPCs.

Hepatitis C genotype 4: What we know and what we don't yet know

Sanaa M. Kamal, Imad A. Nasser – 28 January 2008 – Hepatitis C virus genotype 4 (HCV‐4) is the most common variant of the hepatitis C virus (HCV) in the Middle East and Africa, particularly Egypt. This region has the highest prevelance of HCV worldwide, with more than 90% of infections due to genotype 4. HCV‐4 has recently spread in several Western countries, particularly in Europe, due to variations in population structure, immigration, and routes of transmission. The features of HCV‐4 infection and the appropriate therapeutic regimen have not been well characterized.

Behavior therapy for nonalcoholic fatty liver disease: The need for a multidisciplinary approach

Stefano Bellentani, Riccardo Dalle Grave, Alessandro Suppini, Giulio Marchesini, Fatty Liver Italian Network (FLIN) – 26 January 2008 – Nonalcoholic fatty liver disease (NAFLD) is systematically associated with insulin resistance and the metabolic syndrome, where behavior therapy remains the primary treatment, simultaneously addressing all the clinical and biochemical defects.

The causes of primary biliary cirrhosis: Convenient and inconvenient truths

M. Eric Gershwin, Ian R. Mackay – 26 January 2008 – The most difficult issue in autoimmunity remains etiology. Although data exist on effector mechanisms in many autoimmune diseases, the underlying cause or causes are still generically ascribed to genetics and environmental influences. Primary biliary cirrhosis (PBC) is considered a model autoimmune disease because of its signature antimitochondrial autoantibody (AMA), the homogeneity of clinical characteristics, and the specificity of biliary epithelial cell (BEC) pathology.

Association of gankyrin protein expression with early clinical stages and insulin‐like growth factor‐binding protein 5 expression in human hepatocellular carcinoma

Atsushi Umemura, Yoshito Itoh, Katsuhiko Itoh, Kanji Yamaguchi, Tomoki Nakajima, Hiroaki Higashitsuji, Hitoshi Onoue, Manabu Fukumoto, Takeshi Okanoue, Jun Fujita – 26 January 2008 – Gankyrin (also known as PSMD10) is a liver oncoprotein that interacts with multiple proteins including MDM2 and accelerates degradation of the tumor suppressors p53 and Rb. We produced a monoclonal anti‐gankyrin antibody and immunohistochemically assessed the clinicopathological significance of gankyrin overexpression in 43 specimens of human hepatocellular carcinoma (HCC).

Subscribe to