Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus

Rie Utoh, Chise Tateno, Chihiro Yamasaki, Nobuhiko Hiraga, Miho Kataoka, Takashi Shimada, Kazuaki Chayama, Katsutoshi Yoshizato – 26 January 2008 – We previously identified a small population of replicative hepatocytes in long‐term cultures of human adult parenchymal hepatocytes (PHs) at a frequency of 0.01%‐0.09%. These hepatocytes were able to grow continuously through serial subcultures as colony‐forming parenchymal hepatocytes (CFPHs).

Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells

Konrad L. Streetz, Regis Doyonnas, Dirk Grimm, D. Denison Jenkins, Sally Fuess, Scott Perryman, Joseph Lin, Christian Trautwein, Judith Shizuru, Helen Blau, Karl G. Sylvester, Mark A. Kay – 26 January 2008 – The lack of adequate donor organs is a major limitation to the successful widespread use of liver transplantation for numerous human hepatic diseases. A desirable alternative therapeutic option is hepatocyte transplantation (HT), but this approach is similarly restricted by a shortage of donor cells and by immunological barriers.

Etiology‐dependent molecular mechanisms in human hepatocarcinogenesis

Christof Schlaeger, Thomas Longerich, Claudia Schiller, Peter Bewerunge, Arianeb Mehrabi, Grischa Toedt, Jörg Kleeff, Volker Ehemann, Roland Eils, Peter Lichter, Peter Schirmacher, Bernhard Radlwimmer – 26 January 2008 – Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is characterized by aggressive tumor behavior coupled with poor prognosis. Various etiologies have been linked to HCC development, most prominently chronic hepatitis B and C virus infections as well as chronic alcohol consumption.

Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes

Kosuke Matsui, Mikio Nishizawa, Takashi Ozaki, Tominori Kimura, Iwao Hashimoto, Masanori Yamada, Masaki Kaibori, Yasuo Kamiyama, Seiji Ito, Tadayoshi Okumura – 26 January 2008 – During inflammation, inducible nitric oxide synthase (iNOS) is induced to generate the important mediator nitric oxide (NO). Interleukin 1β (IL‐1β) induces iNOS messenger RNA (mRNA), iNOS protein, and NO in rat hepatocytes.

Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers

Indra Neil Guha, Julie Parkes, Paul Roderick, Dipanker Chattopadhyay, Richard Cross, Scott Harris, Philip Kaye, Alastair D. Burt, Steve D. Ryder, Guruprasad P. Aithal, Christopher P. Day, William M. Rosenberg – 26 January 2008 – The detection of fibrosis within nonalcoholic fatty liver disease (NAFLD) is important for ascertaining prognosis and the stratification of patients for emerging therapeutic intervention.

Therapeutic RNA silencing of Cys‐X3‐Cys chemokine ligand 1 gene prevents mice from adenovirus vector‐induced acute liver injury

Qingfeng Chen, Haiming Wei, Rui Sun, Jian Zhang, Zhigang Tian – 26 January 2008 – Gene therapy using adenovirus vectors may induce acute liver injury. Tissue injury induced by an adenovirus is likely associated with elevated expression of the Cys‐X3‐Cys chemokine ligand 1 (CX3CL1)/fractalkine (FKN) protein at the site of inflammation. However, the extent to which the actions of FKN contribute to liver injury remains unclear.

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