Daniel S. Emmett, Andrew Feranchak, Gordan Kilic, Livia Puljak, Bonnie Miller, Svjetlana Dolovcak, Ryan McWilliams, R. Brian Doctor, J. Gregory Fitz – 26 January 2008 – Ionotrophic purinergic (P2X) receptors function as receptor‐gated cation channels, where agonist binding leads to opening of a nonselective cation pore permeable to both Na+ and Ca2+.
Anais Vallet‐Pichard, Vincent Mallet, Stanislas Pol – 26 January 2008
Masayuki Adachi, David A. Brenner – 26 January 2008 – Adiponectin is an adipocyte‐derived, antidiabetic, antiatherogenic adipocytokine that is present in serum as 3 isoforms. Decreased plasma adiponectin levels are closely associated with the severity of nonalcoholic fatty liver diseases. This study was designed to elucidate a role of adiponectin and its mediator adenosine monophosphate–activated protein kinase (AMPK) on proliferation of activated hepatic stellate cells (HSCs), the key cells promoting fibrosis.
Leonard B. Seeff, Teresa M. Curto, Gyongyi Szabo, Gregory T. Everson, Herbert L. Bonkovsky, Jules L. Dienstag, Mitchell L. Shiffman, Karen L. Lindsay, Anna S. F. Lok, Adrian M. Di Bisceglie, William M. Lee, Marc G. Ghany, HALT‐C Trial Group – 26 January 2008 – Herbal products, used for centuries in Far Eastern countries, are gaining popularity in western countries. Surveys indicate that persons with chronic hepatitis C (CHC) often use herbals, especially silymarin (milk thistle extract), hoping to improve the modest response to antiviral therapy and reduce side effects.
Philippe Colson, Nabil Brouk, Frédérique Lembo, Paul Castellani, Catherine Tamalet, René Gérolami – 26 January 2008
Humberto Reyes – 26 January 2008
Pierre Bedossa, Rami Moucari, Emna Chelbi, Tarik Asselah, Valerie Paradis, Michel Vidaud, Dominique Cazals‐Hatem, Nathalie Boyer, Dominique Valla, Patrick Marcellin – 26 January 2008
Jeremy F L Cobbold, Simon D Taylor‐Robinson – 26 January 2008
Masaaki Shiina, Barbara Rehermann – 26 January 2008 – Previous studies suggested a functional impairment of dendritic cells (DCs) in patients with chronic hepatitis C. To investigate whether this effect was mediated by a direct interaction of hepatitis C virus (HCV) with DCs, we studied the effects of infectious cell culture–produced hepatitis C virus (HCVcc) on peripheral blood mononuclear cells (PBMCs), ex vivo isolated plasmacytoid, and myeloid DCs and in vitro generated monocyte‐derived DCs of healthy blood donors.
Umberto Arena, Francesco Vizzutti, Giampaolo Corti, Silvia Ambu, Cristina Stasi, Silvia Bresci, Stefania Moscarella, Vieri Boddi, Antonio Petrarca, Giacomo Laffi, Fabio Marra, Massimo Pinzani – 26 January 2008 – Liver tissue alterations other than fibrosis may have an impact on liver stiffness measurement. In this study we evaluated 18 patients without a previous clinical history of liver disease, consecutively admitted for acute viral hepatitis.