TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1–Forkhead box M1 regulation loop

Tae Jun Park, Ji Yeon Kim, S. Paul Oh, So Young Kang, Bong Wan Kim, Hee Jung Wang, Kye Yong Song, Hyoung Chin Kim, In Kyoung Lim – 14 January 2008 – A functional and biochemical interaction of TIS21/BTG2/PC3 with Forkhead box M1 (FoxM1), essential transcription factor for hepatocyte regeneration and a master regulator of mitotic gene expression, was explored.

Retracted: Outcome and immune reconstitution of HBV‐specific immunity in patients with reactivation of occult HBV infection after alemtuzumab‐containing chemotherapy regimen

Chee‐Kin Hui, Winnie W. Cheung, Kar‐Wai Leung, Vincent C. C. Cheng, Bone S. F. Tang, Iris W. S. Li, John M. Luk, Nikki P. Lee, Yok‐Lam Kwong, Wing‐Yan Au, Kwok‐Yung Yuen, George K. Lau, Raymond Liang – 14 January 2008 – Retraction: The following article from HEPATOLOGY, “Outcome and immune reconstitution of HBV‐specific immunity in patients with reactivation of occult HBV infection after alemtuzumab‐containing chemotherapy regiment” by Chee‐Kin Hui, Winnie W. Cheung, Kar‐Wai Leung, Vincent C. C. Cheng, Bone S. F. Tang, Iris W. S. Li, John M. Luk, Nikki P.

TRAIL mediates liver injury by the innate immune system in the bile duct–ligated mouse

Alisan Kahraman, Fernando J. Barreyro, Steven F. Bronk, Nathan W. Werneburg, Justin L. Mott, Yuko Akazawa, Howard C. Masuoka, Charles L. Howe, Gregory J. Gores – 10 January 2008 – The contribution of tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL), a death ligand expressed by cells of the innate immune system, to cholestatic liver injury has not been explored. Our aim was to ascertain if TRAIL contributes to liver injury in the bile duct–ligated (BDL) mouse.

Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis

Young Joo Park, Mohammed Qatanani, Steven S. Chua, Jennifer L. LaRey, Stacy A. Johnson, Mitsuhiro Watanabe, David D. Moore, Yoon Kwang Lee – 7 January 2008 – The orphan nuclear hormone receptor small heterodimer partner (SHP) regulates the expression of several genes involved in bile acid homeostasis in the liver. Because bile acid toxicity is a major source of liver injury in cholestatic disease, we explored the role of SHP in liver damage induced by common bile duct ligation (BDL).

Granulin‐epithelin precursor as a therapeutic target for hepatocellular carcinoma

Jenny C. Ho, Ying Chi Ip, Siu Tim Cheung, Yuk Ting Lee, Kui Fat Chan, San Yu Wong, Sheung Tat Fan – 7 January 2008 – Primary liver cancer, hepatocellular carcinoma (HCC), is the fifth most common cancer and the third leading cancer killer in the world. There is no effective therapeutic option for most HCC patients. A new therapeutic strategy is essential. Granulin‐epithelin precursor (GEP, also called progranulin, acrogranin, or PC‐derived growth factor) was identified as a potential therapeutic target for HCC from our earlier genome‐wide expression profiles.

Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfection

Richard K. Sterling, Melissa J. Contos, Paula G. Smith, R. Todd Stravitz, Velimir A. Luketic, Michael Fuchs, Mitchell L. Shiffman, Arun J. Sanyal – 7 January 2008 – Hepatic steatosis has been reported in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfection. However, the features of steatohepatitis, including cytologic ballooning and pericellular fibrosis, its risk factors, and the impact on disease severity in such patients are unknown.

Apolipoprotein B–dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin

Yaakov Nahmias, Jonathan Goldwasser, Monica Casali, Daan van Poll, Takaji Wakita, Raymond T. Chung, Martin L. Yarmush – 7 January 2008 – Hepatitis C virus (HCV) infects over 3% of the world population and is the leading cause of chronic liver disease worldwide. HCV has long been known to associate with circulating lipoproteins, and its interactions with the cholesterol and lipid pathways have been recently described. In this work, we demonstrate that HCV is actively secreted by infected cells through a Golgi‐dependent mechanism while bound to very low density lipoprotein (vLDL).

Blocking transforming growth factor–beta up‐regulates E‐cadherin and reduces migration and invasion of hepatocellular carcinoma cells

Emilia Fransvea, Umberto Angelotti, Salvatore Antonaci, Gianluigi Giannelli – 7 January 2008 – Hepatocellular carcinoma (HCC) treatment is challenging because the mechanisms underlying tumor progression are still largely unknown. Transforming growth factor (TGF)–β1 is considered a crucial molecule in HCC tumorigenesis because increased levels of patients' serum and urine are associated with disease progression. The aim of the present study was to investigate the inhibition of TGF‐β signaling and its impact on HCC progression.

Sulfatase 2 up‐regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma

Jin‐Ping Lai, Dalbir S. Sandhu, Chunrong Yu, Tao Han, Catherine D. Moser, Kenard K. Jackson, Ruben Bonilla Guerrero, Ileana Aderca, Hajime Isomoto, Megan M. Garrity‐Park, Hongzhi Zou, Abdirashid M. Shire, David M. Nagorney, Schuyler O. Sanderson, Alex A. Adjei, Ju‐Seog Lee, Snorri S. Thorgeirsson, Lewis R. Roberts – 7 January 2008 – It has been shown that the heparin‐degrading endosulfatase, sulfatase 1 (SULF1), functions as a liver tumor suppressor, but the role of the related sulfatase, sulfatase 2 (SULF2), in liver carcinogenesis remains to be elucidated.

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