Prevention and management of brain edema in patients with acute liver failure
Fin Stolze Larsen, Julia Wendon – 29 September 2008
Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis
Hye Jung Baek, Sung Chul Lim, Krit Kitisin, Wilma Jogunoori, Yi Tang, M. Blair Marshall, Bibhuti Mishra, Tae Hyun Kim, Kwan Ho Cho, Sang Soo Kim, Lopa Mishra – 26 September 2008 – We have previously demonstrated that 40%‐70% of elf+/− mice spontaneously develop hepatocellular cancer (HCC) within 15 months, revealing the importance of the transforming growth factor‐beta (TGF‐β) signaling pathway in suppressing tumorigenesis in the liver.
Virion half‐life in chronic hepatitis B infection is strongly correlated with levels of viremia
Maura Dandri, John M. Murray, Marc Lutgehetmann, Tassilo Volz, Ansgar W. Lohse, Joerg Petersen – 26 September 2008 – Analysis of hepatitis B virus (HBV) kinetics with mathematical models may disclose new aspects of HBV infection and host response mechanisms.
Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models
Elizabeth P. Newberry, Susan M. Kennedy, Yan Xie, Jianyang Luo, Susan E. Stanley, Clay F. Semenkovich, Roseanne M. Crooke, Mark J. Graham, Nicholas O. Davidson – 26 September 2008 – Liver regeneration is impaired following partial hepatectomy (PH) in mice with genetic obesity and hepatic steatosis and also in wild‐type mice fed a high‐fat diet. These findings contrast with other data showing that liver regeneration is impaired in mice in which hepatic lipid accumulation is suppressed by either pharmacologic leptin administration or by disrupted glucocorticoid signaling.
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Bart J. Veldt, Harry L. A. Janssen – 26 September 2008
The specificity of liver inflammation in mouse models of primary biliary cirrhosis
David E. J. Jones, Jeremy M. Palmer, Alastair D. Burt, John A. Kirby – 26 September 2008
Suppressor of cytokine signaling‐1, a possible cause for regulatory T cells in hepatitis?
Yichuan Xiao, Yanyun Zhang – 26 September 2008
Hepatitis E: Does it cause chronic hepatitis?
Rakesh Aggarwal – 26 September 2008
High relapse rate seen at week 72 for patients treated with R1626 combination therapy
Paul Pockros, David Nelson, Eliot Godofsky, Maribel Rodriguez‐Torres, Gregory T. Everson, Michael W. Fried, Reem Ghalib, Stephen Harrison, Lisa Nyberg, Mitchell L. Shiffman, Anna Chan, George Hill – 26 September 2008
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis
Maria J. Perugorria, M. Ujue Latasa, Alexandra Nicou, Hugo Cartagena‐Lirola, Josefa Castillo, Saioa Goñi, Umberto Vespasiani‐Gentilucci, Maria G. Zagami, Sophie Lotersztajn, Jesús Prieto, Carmen Berasain, Matias A. Avila – 26 September 2008 – The hepatic wound‐healing response to chronic noxious stimuli may lead to liver fibrosis, a condition characterized by excessive deposition of extracellular matrix. Fibrogenic cells, including hepatic stellate cells and myofibroblasts, are activated in response to a variety of cytokines, growth factors, and inflammatory mediators.