Microtubule acetylation and stability may explain alcohol‐induced alterations in hepatic protein trafficking
Rohan A. Joseph, Blythe D. Shepard, George T. Kannarkat, Tara M. Rutledge, Dean J. Tuma, Pamela L. Tuma – 27 December 2007 – We have been using polarized hepatic WIF‐B cells to examine ethanol‐induced liver injury. Previously, we determined microtubules were more highly acetylated and more stable in ethanol‐treated WIF‐B cells. We proposed that the ethanol‐induced alterations in microtubule dynamics may explain the ethanol‐induced defects in membrane trafficking that have been previously documented.