Microtubule acetylation and stability may explain alcohol‐induced alterations in hepatic protein trafficking

Rohan A. Joseph, Blythe D. Shepard, George T. Kannarkat, Tara M. Rutledge, Dean J. Tuma, Pamela L. Tuma – 27 December 2007 – We have been using polarized hepatic WIF‐B cells to examine ethanol‐induced liver injury. Previously, we determined microtubules were more highly acetylated and more stable in ethanol‐treated WIF‐B cells. We proposed that the ethanol‐induced alterations in microtubule dynamics may explain the ethanol‐induced defects in membrane trafficking that have been previously documented.

Predicting immunosuppressant dosing in the early postoperative period with noninvasive indocyanine green elimination following orthotopic liver transplantation

Brian M. Parker, Jacek B. Cywinski, Joan M. Alster, Samuel A. Irefin, Marc Popovich, Michael Beven, John J. Fung – 27 December 2007 – Twenty adult patients undergoing orthotopic liver transplantation (OLT) were enrolled in this study, with the noninvasive indocyanine green plasma disappearance rate (ICG‐PDR) measured both during and after OLT to assess the relationship between ICG‐PDR and the ability of patients to achieve therapeutic postoperative tacrolimus immunosuppressant blood levels.

Human herpesvirus 6 infection in adult living related liver transplant recipients

Masahiro Ohashi, Ken Sugata, Masaru Ihira, Yoshizo Asano, Hiroto Egawa, Yasutsugu Takada, Shinji Uemoto, Tetsushi Yoshikawa – 27 December 2007 – To analyze human herpesvirus 6 (HHV‐6) infection in adult living related liver transplantation, we performed a virological analysis, including viral isolation, serological assay, and real‐time polymerase chain reaction, of serially collected blood samples from 67 recipients. In addition, cytokine levels were measured to determine their role in viral reactivation.

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