Long‐term therapy with clevudine for chronic hepatitis B can be associated with myopathy characterized by depletion of mitochondrial DNA
Jung Im Seok, Dong Kuck Lee, Chang Hyeong Lee, Min Su Park, Sun Young Kim, Hyang‐Sook Kim, Hee‐Young Jo, Chang Hun Lee, Dae‐Seong Kim – 28 May 2009 – Clevudine (Revovir), a pyrimidine nucleoside analogue, is a recently introduced antiviral drug. Clinical trials have demonstrated potent, sustained antiviral activity against hepatitis B virus without specific adverse events. The lack of cytotoxicity and absence of an effect on mitochondrial function have been considered the reasons for the fewer adverse events.