Long‐term therapy with clevudine for chronic hepatitis B can be associated with myopathy characterized by depletion of mitochondrial DNA

Jung Im Seok, Dong Kuck Lee, Chang Hyeong Lee, Min Su Park, Sun Young Kim, Hyang‐Sook Kim, Hee‐Young Jo, Chang Hun Lee, Dae‐Seong Kim – 28 May 2009 – Clevudine (Revovir), a pyrimidine nucleoside analogue, is a recently introduced antiviral drug. Clinical trials have demonstrated potent, sustained antiviral activity against hepatitis B virus without specific adverse events. The lack of cytotoxicity and absence of an effect on mitochondrial function have been considered the reasons for the fewer adverse events.

Donor livers with steatosis are safe to use in hepatitis C virus–positive recipients

Patrizia Burra, Massimiliano Loreno, Francesco Paolo Russo, Giacomo Germani, Alessandra Galligioni, Marco Senzolo, Umberto Cillo, Giacomo Zanus, Stefano Fagiuoli, Massimo Rugge – 28 May 2009 – Whether donor graft steatosis affects liver function and influences survival after liver transplantation is still open to debate. The aim of this study was to assess the impact of donor graft steatosis on long‐term liver histology after liver transplantation.

Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease

Kerry‐Lee Milner, David van der Poorten, Aimin Xu, Elisabetta Bugianesi, James G. Kench, Karen S. L. Lam, Donald J. Chisholm, Jacob George – 28 May 2009 – Several circulating cytokines are increased with obesity and may combine with the influence of visceral fat to generate insulin resistance, inflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD).

Impact of the donor risk index on the outcome of hepatitis C virus–positive liver transplant recipients

Daniel G. Maluf, Erick B. Edwards, R. Todd Stravitz, H. Myron Kauffman – 28 May 2009 – We have investigated the impact of the donor risk index (DRI) on the outcome of hepatitis C virus (HCV)–infected patients undergoing liver transplantation (LTx). Retrospective analysis was performed from the Organ Procurement and Transplantation Network database (January 1, 2000 to June, 2006). The DRI was calculated as described by Feng et al. (Am J Transplant 2006;6:783–790). Model for End‐Stage Liver Disease (MELD) exceptions were excluded from the analysis.

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