Epigenetic identification of ubiquitin carboxyl‐terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors
Jun Yu, Qian Tao, Kin F. Cheung, Hongchuan Jin, Fan Fong Poon, Xian Wang, Hongyu Li, Yuen Y. Cheng, Christoph Röcken, Matthias P. A. Ebert, Anthony T. C. Chan, Joseph J. Y. Sung – 26 March 2008 – The ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) is a carboxyl‐terminal ubiquitin hydrolase regulating cellular ubiquitin levels, recently suggested as a tumor suppressor. However, the role of UCHL1 in hepatocellular carcinoma (HCC) is not clear.