Utility of liver allograft biopsy obtained at procurement

Irene J. Lo, Jay H. Lefkowitch, Nikki Feirt, Barbara Alkofer, Cindy Kin, Benjamin Samstein, James V. Guarrera, John F. Renz – 6 March 2008 – Extended‐donor criteria (EDC) liver allografts potentiate the role of procurement biopsy in organ utilization. To expedite allocation, histologic evaluation is routinely performed upon frozen‐section (FS) specimens by local pathologists.

Should trichrome stain be used on all post–liver transplant biopsies with hepatitis c virus infection to estimate the fibrosis score?

David Tretheway, Ashok Jain, Randi LaPoint, Rajeev Sharma, Mark Orloff, Patricia Milot, Adel Bozorgzadeh, Charlotte Ryan – 6 March 2008 – Recurrent hepatitis C is virtually universal after liver transplantation; however, an individual patient's clinical course and disease burden are highly variable and difficult to predict. The fibrosis score determined on posttransplant biopsies appears to be a sensitive and specific marker of disease progression and severity.

Hepatitis C virus reinfection in liver transplant patients: Evaluation of liver damage progression with echo‐color doppler

Massimo Bolognesi, Cristina Quaglio, Giancarlo Bombonato, Maria Guido, Luisa Cavalletto, Liliana Chemello, Carlo Merkel, Massimo Rugge, Angelo Gatta, David Sacerdoti – 6 March 2008 – Liver transplant recipients are a model of rapid progression of hepatitis C virus (HCV)–related liver disease, from normal to cirrhosis. The aim of the study was the analysis of the relationship between portohepatic hemodynamics and modification in liver histology during the progression of HCV liver disease after transplant. Patients transplanted for HCV cirrhosis were considered for the study.

Prevalence and significance of occult hepatitis B in a liver transplant population with chronic hepatitis C

Kirti Shetty, Munira Hussain, Lei Nei, K. Rajender Reddy, Anna S.F. Lok – 6 March 2008 – Occult hepatitis B virus (HBV) infection is defined as the detection of HBV deoxyribonucleic acid (DNA) in the serum or liver tissue of individuals who test negative for hepatitis B surface antigen (HBsAg). We undertook a prospective study to evaluate the significance and course of occult HBV in patients with hepatitis C virus (HCV) cirrhosis undergoing orthotopic liver transplantation (OLT).

Health‐related quality of life in chronic hepatitis B patients

Siew Chin Ong, Belinda Mak, Myat Oo Aung, Shu‐Chuen Li, Seng‐Gee Lim – 3 March 2008 – The relationship between stages of chronic hepatitis B liver disease and health‐related quality of life (HRQoL) is an important aspect of the overall management of hepatitis B virus (HBV) infection, yet is not well characterized. Consequently we sought to examine HRQoL in HBV patients, stratified by disease severity, compared with normal controls and hypertensive patients, using the Short Form 36 Health Survey (SF‐36) and the EQ‐5D self‐report questionnaire.

Oxygen desaturation during sleep in hepatopulmonary syndrome

David T. Palma, George M. Philips, Miguel R. Arguedas, Susan M. Harding, Michael B. Fallon – 29 February 2008 – Sleep alters respiratory mechanics and gas exchange, which can adversely affect arterial oxygenation. Whether sleep affects oxygenation in hepatopulmonary syndrome is unknown. The aim of this study was to assess oxygen desaturation during sleep in hepatopulmonary syndrome. Twenty adults with cirrhosis including 10 controls and 10 patients with hepatopulmonary syndrome underwent home pulse‐oximetry during sleep.

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