Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways

Takashi Nitta, Jae‐Sung Kim, Dagmara Mohuczy, Kevin E. Behrns – 2 May 2008 – Hepatocytes that reside in a chronically‐injured liver have altered growth responses compared to hepatocytes in normal liver. Transforming growth factor beta (TGFβ) is upregulated in the cirrhotic liver, and cirrhotic hepatocytes, unlike normal hepatocytes exposed to this cytokine, exhibit decreased apoptosis. In fetal hepatocytes, TGFβ also induces epithelial‐mesenchymal transition (EMT) and signaling changes in cell survival pathways.

Activation of nuclear factor E2‐related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development

Silke Marhenke, Jutta Lamlé, Laura Elisa Buitrago‐Molina, José Manuel Fernández Cañón, Robert Geffers, Milton Finegold, Michael Sporn, Masayuki Yamamoto, Michael P. Manns, Markus Grompe, Arndt Vogel – 2 May 2008 – In tyrosinemia type 1 (HT1), accumulation of toxic metabolites results in oxidative stress and DNA damage, leading to a high incidence of hepatocellular carcinomas. Nuclear factor erythroid‐2 related factor 2 (Nrf2) is a key transcription factor important for cellular protection against oxidative stress and chemical induced liver damage.

In vivo antisense oligonucleotide reduction of NPC1 expression as a novel mouse model for Niemann Pick type C– associated liver disease

Victoria M. Rimkunas, Mark J. Graham, Rosanne M. Crooke, Laura Liscum – 25 April 2008 – Niemann‐Pick type C (NPC) is a fatal autosomal recessive lipidosis that is characterized by lysosomal storage of cholesterol and glycosphingolipids. Patients exhibit prolonged neonatal jaundice, hepatosplenomegaly, and progressive neurodegeneration that generally result in death by the teen years. Most clinical cases are caused by mutations in the NPC1 gene. Current mouse models of NPC are not well suited for studying the liver disease due to the rapidly progressing neurological disease.

Reply:

Sanaa Kamal, Michelle Schardell, Samer El Kamary, Mohamed Hashem, Hoda Mansour, Amany Sayed Ibrahim – 25 April 2008

Subscribe to