Minichromosome maintenance protein‐2–positive portal tract lymphocytes distinguish acute cellular rejection from hepatitis C virus recurrence after liver transplantation

Esther Unitt, William Gelson, Susan E. Davies, Nicholas Coleman, Graeme J. M. Alexander – 25 February 2009 – Hepatitis C virus (HCV) is a leading indication for liver transplantation worldwide, but graft infection with HCV frequently leads to hepatic fibrosis. Acute cellular rejection (ACR) can be difficult to distinguish confidently from HCV, even with histology, but accurate diagnosis is critical because treatment of ACR may accelerate HCV‐related graft injury.

Clinically relevant differences in the model for end‐stage liver disease and model for end‐stage liver disease–sodium scores determined at three university‐based laboratories of the same area

Xavier Xiol, Pere Gines, Lluis Castells, Jorge Twose, Alba Ribalta, Xavier Fuentes‐Arderiu, Santiago Rodriguez, Jose Castellote, Miquel Navasa, Roser Deulofeu – 25 February 2009 – The Model for End‐Stage Liver Disease (MELD) score is considered an objective and reliable measure of liver disease severity. However, the use of specific laboratory methodologies may introduce significant and clinically relevant variations into the score. It has been suggested that the incorporation of sodium into MELD (MELD‐Na) can provide a more accurate survival prediction than MELD alone.

Living liver donor death related to complications of myeloma

Emmanuel Melloul, Federica Dondero, Catherine Paugam‐Burtz, Lila Bouadma, Bertrand Arnulf, Jacques Belghiti – 25 February 2009 – We report a donor death after right hepatectomy for living donor transplantation due to an undiagnosed myeloma. The 47‐year‐old donor, who was the 147th case performed in our department, was in excellent health without any abnormalities in the preoperative investigations.

Techniques of cardiac output measurement during liver transplantation: Arterial pulse wave versus thermodilution

Peter Nissen, Johannes J. Van Lieshout, Srdan Novovic, Morten Bundgaard‐Nielsen, Niels H. Secher – 25 February 2009 – In this study, we compared continuous cardiac output (CO) obtained from the femoral arterial pressure by simulation of an aortic input impedance model [model‐simulated cardiac output (MCO)] to thermodilution cardiac output (TDCO) determined by bolus injection during liver transplantation. Both variables were measured in 39 adult patients (13 females) every 10th minute during liver transplant surgery.

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