Patient‐centered care: Key elements applicable to chronic liver disease

Manisha Verma, Mayur Brahmania, Brett E. Fortune, Sumeet K. Asrani, Michael Fuchs, Michael L. Volk – 15 June 2022 – Chronic liver disease (CLD) is a progressive illness with high symptom burden and functional and cognitive impairment, often with comorbid mental and substance use disorders. These factors lead to significant deterioration in quality of life, with immense burden on patients, caregivers, and healthcare.

Waitlist mortality of young patients with biliary atresia: Impact of allocation policy and living donor liver transplantation

Hedayatullah Esmati, Marieke Rosmalen, Patrick F. Rheenen, Marieke T. Boer, Aad P. Berg, Hubert P. J. Doef, Michel Rayar, Ruben H.J. Kleine, Robert J. Porte, Vincent E. Meijer, Henkjan J. Verkade – 13 June 2022 – Patients with biliary atresia (BA) below 2 years of age in need of a transplantation largely rely on partial grafts from deceased donors (deceased donor liver transplantation [DDLT]) or living donors (living donor liver transplantation [LDLT]).

Iron overload disorders

Christine C. Hsu, Nizar H. Senussi, Kleber Y. Fertrin, Kris V. Kowdley – 13 June 2022 – Iron overload disorders represent a variety of conditions that lead to increased total body iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron saturation can be commonly encountered in the evaluation of elevated liver enzymes. Confirmatory homeostatic iron regulator (HFE) genetic testing for C282Y and H63D, mutations most encountered in hereditary hemochromatosis, should be pursued in evaluation of hyperferritinemia.

Alpha‐kinase 1 (ALPK1) agonist DF‐006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B

Cong Xu, Jieqing Fan, Danyang Liu, Aimaier Tuerdi, Juanjuan Chen, Yuning Wei, Yanfang Pan, Huaixin Dang, Xiong Wei, Ashraf Siddig Yousif, Jeysen Yogaratnam, Qiong Zhou, Henri Lichenstein, Tian Xu – 13 June 2022

Logistical burden of offers and allocation inefficiency in circle‐based liver allocation

Nicholas L. Wood, Douglas N. VanDerwerken, Dorry L. Segev, Sommer E. Gentry – 12 June 2022 – Recent changes to liver allocation replaced donor service areas with circles as the geographic unit of allocation. Circle‐based allocation might increase the number of transplantation centers and candidates required to place a liver, thereby increasing the logistical burden of making and responding to offers on organ procurement organizations and transplantation centers.

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