Tetrahydroxylated bile acids improve cholestatic liver and bile duct injury in the Mdr2−/− mouse model of sclerosing cholangitis via immunomodulatory effects

Claudia D. Fuchs, Emmanuel D. Dixon, Tim Hendrikx, Veronika Mlitz, Annika Wahlström, Marcus Ståhlman, Hubert Scharnagl, Tatjana Stojakovic, Christoph J. Binder, Hanns‐Ulrich Marschall, Michael Trauner – 11 June 2022 – Bile salt export pump (Bsep) (Abcb11)−/− mice are protected from acquired cholestatic injury due to metabolic preconditioning with a hydrophilic bile acid (BA) pool with formation of tetrahydroxylated bile acids (THBAs).

A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes

Ariunaa Sumiyadorj, Kazuhisa Murai, Tetsuro Shimakami, Kazuyuki Kuroki, Tomoki Nishikawa, Masaki Kakuya, Atsumu Yamada, Ying Wang, Atsuya Ishida, Takayoshi Shirasaki, Shotaro Kawase, Ying‐Yi Li, Hikari Okada, Kouki Nio, Kazunori Kawaguchi, Taro Yamashita, Yoshio Sakai, Davaadorj Duger, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko – 11 June 2022 – For the development of antiviral agents to eliminate hepatitis B virus (HBV), it is essential to establish an HBV cell culture system that can easily monitor HBV infection.

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Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers – 10 June 2022

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