Low‐dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation

Christian E. Oberkofler, Dimitri A. Raptis, Philip C. Müller, Richard X. Sousa da Silva, Kuno Lehmann, Takahiro Ito, Timothy Owen, Joerg‐Matthias Pollok, Alessandro Parente, Andrea Schlegel, Peregrina Peralta, Erin Winter, Markus Selzner, Margot Fodor, Manuel Maglione, Manuel Jaklitsch, Hugo P. Marques, Mariana Chavez‐Villa, Alan Contreras, Philipp Kron, Peter Lodge, Scott Alford, Abbas Rana, Paolo Magistri, Fabrizio Di Benedetto, Bethany Johnson, Varvara Kirchner, Francis Bauldrick, Karim J. Halazun, Omid Ghamarnedjad, Arianeb Mehrabi, Samanta Teixeira Basto, Eduardo S. M.

Implementation of a controlled human infection model for evaluation of HCV vaccine candidates

Eleanor Barnes, Graham S. Cooke, Georg M. Lauer, Raymond T. Chung – 22 June 2022 – Hepatitis C virus (HCV) remains a major global health concern. Directly acting antiviral (DAA) drugs have transformed the treatment of HCV. However, it has become clear that, without an effective HCV vaccine, it will not be possible to meet the World Health Organization targets of HCV viral elimination. Promising new vaccine technologies that generate high magnitude antiviral T and B cell immune responses and significant new funding have recently become available, stimulating the HCV vaccine pipeline.

Noncellular components in the liver cancer stem cell niche: Biology and potential clinical implications

Ka‐Hei Lam, Stephanie Ma – 20 June 2022 – Cancer stem cells (CSCs) are now recognized as one of the major root causes of therapy failure and tumor recurrence in hepatocellular carcinoma (HCC). Early studies in the field focused primarily on the intrinsic regulators of CSC maintenance, but in recent years, mounting evidence has demonstrated the presence and role of extrinsic regulators in the tumor microenvironment (TME) in the control of liver CSCs.

Multicenter study of racial and ethnic inequities in liver transplantation evaluation: Understanding mechanisms and identifying solutions

Alexandra T. Strauss, Carolyn N. Sidoti, Tanjala S. Purnell, Hannah C. Sung, John W. Jackson, Scott Levin, Vedant S. Jain, Daniel Malinsky, Dorry L. Segev, James P. Hamilton, Jacqueline Garonzik‐Wang, Stephen H. Gray, Macey L. Levan, Joseph R. Scalea, Andrew M. Cameron, Ahmet Gurakar, Ayse P. Gurses – 20 June 2022 – Racial and ethnic disparities persist in access to the liver transplantation (LT) waiting list; however, there is limited knowledge about underlying system‐level factors that may be responsible for these disparities.

Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis

Brian K. Chung, Jonas Øgaard, Henrik Mikael Reims, Tom H. Karlsen, Espen Melum – 19 June 2022 – Liver fibrosis and cirrhosis have limited therapeutic options and represent a serious unmet patient need. Recent use of single‐cell RNA sequencing (scRNAseq) has identified enriched cell types infiltrating cirrhotic livers but without defining the microanatomical location of these lineages thoroughly.

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