David Durantel, Sandra Carrouée‐Durantel, Bettina Werle‐Lapostolle, Marie‐Noëlle Brunelle, Christian Pichoud, Christian Trépo, Fabien Zoulim – 7 March 2007 – Resistance of hepatitis B virus (HBV) to antivirals has become a major clinical problem. Our objective was to develop a new method for the cloning of naturally occurring HBV genomes and a phenotypic assay capable of assessing HBV drug susceptibility and DNA synthesis capacity in vitro.

7 March 2007

Robert Thimme, Hans‐Christian Spangenberg, Hubert E. Blum – 7 March 2007 – Background: Neither previous hepatitis C (HCV) infection nor vaccination with HCV‐derived antigens protects against reinfection. However, HCV infection and vaccination in chimpanzees has been shown to reduce the magnitude and duration of viraemia with re‐challenge. We aimed to establish whether similar immunity could be achieved in man.

Katarína Vajdová, Rolf Graf, Pierre‐Alain Clavien – 7 March 2007

Neil D. Theise – 7 March 2007

Hartmut Jaeschke – 7 March 2007 – Microarray technology allows the simultaneous analysis of mRNA expression levels of thousands of genes. In the field of toxicogenomics, this technology could help to identify potentially unsafe compounds based on the changes in mRNA expression patterns they induce. Rodent in vivo and in vitro systems are currently the experimental models of choice for predictive toxicology, especially in early phases of development.

Douglas M. Heuman, Souheil G. Abou‐Assi, Adil Habib, Leslie M. Williams, R. Todd Stravitz, Arun J. Sanyal, Robert A. Fisher, Anastasios A. Mihas – 7 March 2007 – Despite the adoption of “sickest first” liver transplantation, pretransplant death remains common, and many early deaths occur despite initially low Model for End‐stage Liver Disease (MELD) scores. From 1997–2003, we studied 507 cirrhotic United States veterans referred for consideration of liver transplantation to identify additional predictors of early mortality.

Matthew T. Nichols, Elsa Gidey, Tom Matzakos, Rolf Dahl, Greg Stiegmann, Raj J. Shah, Jared J. Grantham, J. Gregory Fitz, R. Brian – 7 March 2007 – The principal extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD) involves formation of liver cysts derived from intrahepatic bile ducts. Autocrine and paracrine factors secreted into the cyst would be positioned to modulate the rate of hepatic cyst growth. The aim of this study was to identify potential growth factors present in human ADPKD liver cyst fluid.

Katherine A. McGlynn, Michael N. Edmonson, Rita A. Michielli, W. Thomas London, Wen Yao Lin, Gong‐Chao Chen, Fu‐Min Shen, Kenneth H. Buetow – 7 March 2007 – Primary hepatocellular carcinoma (HCC) is a significant cause of cancer morbidity and mortality on the global scale. Although epidemiologic studies have identified major risk factors for HCC, the sequence of oncogenic events at the molecular level remains poorly understood. While genetic allele loss appears to be a common event, the significance of the loss is not clear.

Stephen F. Stewart, Julian B. Leathart, Yuanneng Chen, Ann K. Daly, Roberta Rolla, Daria Vay, Elisa Mottaran, Matteo Vidali, Emanuele Albano, Chris P. Day – 7 March 2007 – The role of genetic factors in the pathogenesis of alcohol‐induced liver disease (ALD) is receiving increasing attention. Recently, it has been reported that homozygosity for a valine to alanine substitution in the mitochondrial targeting sequence of manganese superoxide dismutase (Mn‐SOD) represents a risk factor for severe ALD.