Zhen Fan Yang, Patricia Ngai, Chi Keung Lau, David W. Ho, Ka Ho Tam, Chi Tat Lam, Ronnie T. Poon, Sheung Tat Fan – 29 March 2007 – This study aims to investigate the potential role of endogenous interleukin (IL)‐10 in long‐term liver allograft survival induced by delayed immunosuppression (FK506 days 2‐7). Liver transplantation was performed by using Dark Agouti and Lewis rats as donors and recipients, respectively. The delayed immunosuppression protocol induced indefinite allograft survival.

Zhen Fan Yang, David Wing Yuen Ho, Patricia Ngai, Chi Keung Lau, Yi Zhao, Ronnie Tung Ping Poon, Sheung Tat Fan – 29 March 2007 – The present study aims to investigate the potential therapeutic role of interleukin‐10 (IL‐10) in small‐for‐size liver transplantation. A syngenic rat orthotopic liver transplantation model was performed using either whole or 40% liver volume of Lewis rats as grafts according to the experimental design. IL‐10 was given to the 40% grafts right after reperfusion, and also at 24 and 48 hours after transplantation.

Kristin L. Mekeel, Max R. Langham, Regino Gonzalez‐Peralta, Shiro Fujita, Alan W. Hemming – 29 March 2007 – Severe liver disease is an unusual but potentially fatal complication of sickle‐cell disease (SCD). Liver transplantation has been complicated by ongoing SCD and thrombosis. We reviewed 214 pediatric transplants done at our institution from 1990 to 2005. Three patients were transplanted for complications of SCD, including intrahepatic cholestasis and viral hepatitis. Overall patient and graft survival was 66%. One patient died after 6 years from a subdural hematoma.

Lawrence S. Friedman – 29 March 2007

Maud Bessems, Benedict M. Doorschodt, Joe L.P. Kolkert, Reeta L. Vetelainen, Arlene K. van Vliet, Heleen Vreeling, Jan van Marle, Thomas M. van Gulik – 29 March 2007 – Liver grafts are frequently discarded due to steatosis. Steatotic livers can be classified as suboptimal and deteriorate rapidly during hypothermic static preservation, often resulting in graft nonfunction. Hypothermic machine perfusion (MP) has been introduced for preservation of donor livers instead of cold storage (CS), resulting in superior preservation outcomes.

Xavier Forns, José A. Carrión, Miquel Navasa, Juan Carlos García‐Pagan, Miquel Bruguera, Jaume Bosch – 29 March 2007

Ian P.J. Alwayn, Robert J. Porte – 29 March 2007

Edson Abdala, Carlos Eduardo Sandoli Baía, Sérgio Mies, Paulo Celso Bosco Massarollo, Norma de Paula Cavalheiro, Vania Regina Mollo Baía, Conceição Aparecida Félix Inácio, Henry Corazza Sef, Antonio Alci Barone – 29 March 2007 – The aim of this study was to evaluate the bacterial translocation in liver transplantation (LT), comparing the conventional and the piggyback methods. A total of 32 patients were randomized into the 2 groups. Samples of blood were collected from the radial artery, portal vein (PV) and hepatic vein (HV), in up to 120 minutes postreperfusion.

Megan H. Keane, Henk Overmars, Thomas M. Wikander, Sacha Ferdinandusse, Marinus Duran, Ronald J. A. Wanders, Phyllis L. Faust – 28 March 2007 – The marked deficiency of peroxisomal organelle assembly in the PEX2−/− mouse model for Zellweger syndrome provides a unique opportunity to developmentally and biochemically characterize hepatic disease progression and bile acid products. The postnatal survival of homozygous mutants enabled us to evaluate the response to bile acid replenishment in this disease state.

Christophe Frémin, Frédéric Ezan, Pierre Boisselier, Anne Bessard, Gilles Pagès, Jacques Pouysségur, Georges Baffet – 28 March 2007 – The mitogen‐activated protein kinases (MAPKs) ERK1 and ERK2 have been implicated in various physiological events, and specific targeting of these MAPKs could affect cell proliferation in many cell types. First, to evaluate the potential specific roles of these two MAPKs, we analyzed the mitogenic response in regenerating liver after partial hepatectomy (PH) and in primary culture of hepatocytes isolated from ERK1‐deficient mice.