Minimal anhepatic technique for living donor liver transplantation using right liver graft
Seong Hoon Kim, Jun‐sik Yoo, Sung‐Sik Han, Sang Jae Park, Soon‐ae Lee, Woo Jin Lee, Joong‐Won Park, Chang‐Min Kim – 29 October 2007
Biliary atresia: A transplant perspective
Benjamin L. Shneider, George V. Mazariegos – 29 October 2007
Management of hepatocellular carcinoma on the waiting list before liver transplantation: Time for controlled trials?
Pietro Majno, Emiliano Giostra, Gilles Mentha – 29 October 2007
Public and professional attitudes to transplanting alcoholic patients
James Neuberger – 29 October 2007 – The discrepancy between the number of people who might benefit from liver transplantation continues to exceed the availability of donor livers available, so rationing of grafts must occur.
The problem of HCC and liver transplantation
29 October 2007
Introducing T.H.E. corner
Hugo Vargas – 29 October 2007
Antimitochondrial antibodies in acute liver failure: Implications for primary biliary cirrhosis
Patrick S. C. Leung, Lorenzo Rossaro, Paul A. Davis, Ogyi Park, Atsushi Tanaka, Kentaro Kikuchi, Hiroshi Miyakawa, Gary L. Norman, William Lee, M.
Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory‐Denk bodies
Nam‐On Ku, Pavel Strnad, Bi‐Hui Zhong, Guo‐Zhong Tao, M. Bishr Omary – 29 October 2007 – Keratin polypeptides 8 and 18 (K8/K18) are the cytoskeletal intermediate filament proteins of hepatocytes while K8/K18/K19 are the keratins of hepatobiliary ductal cells. Hepatocyte K8/K18 are highly abundant and behave as stress proteins with injury‐inducible expression.
Human skin fibroblasts: From mesodermal to hepatocyte‐like differentiation
Philippe A. Lysy, Françoise Smets, Catherine Sibille, Mustapha Najimi, Etienne M. Sokal – 29 October 2007 – The phenotypic homology of fibroblasts and mesenchymal stem cells (MSCs) has been recently described. Our study investigated the in vitro potential of human skin fibroblasts to differentiate into mesodermal (osteocyte and adipocyte) and endodermal (hepatocyte) cell lineages by comparison with human bone marrow (hBM) MSCs. The endodermal potential of fibroblasts was then explored in vivo in a mouse model of liver injury.
Mechanisms of protection by the betaine‐homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes
Cheng Ji, Masao Shinohara, John Kuhlenkamp, Christine Chan, Neil Kaplowitz – 29 October 2007 – Betaine‐homocysteine methyltransferase (BHMT) regulates homocysteine levels in the liver. We previously reported that the alteration of BHMT is associated with alcoholic liver steatosis and injury. In this study, we tested whether BHMT protects hepatocytes from homocysteine‐induced injury and lipid accumulation. Both BHMT transfectants of HepG2 cells and primary mouse hepatocytes with suppressed BHMT were generated.