Recurrent hepatic lymphangiomatosis after orthotopic liver transplantation

Seong H. Ra, Robert F. Bradley, Michael C. Fishbein, Ronald W. Busuttil, David S.K. Lu, Charles R. Lassman – 29 October 2007 – Hepatic lymphangiomatosis is a rare disease characterized by an abnormal lymphatic proliferation involving the liver alone, liver and spleen, or multiple organs. Hepatic lymphangiomatosis becomes symptomatic secondary to compression or replacement of the normal parenchyma, which can lead to liver failure. Resection and orthotopic liver transplantation (OLT) can be used as treatment for this disease.

Herpes simplex virus hepatitis: An analysis of the published literature and institutional cases

John P. Norvell, Andres T. Blei, Borko D. Jovanovic, Josh Levitsky – 27 September 2007 – Hepatitis is a rare complication of herpes simplex virus (HSV), often leading to acute liver failure (ALF), liver transplantation (LT), and/or death. Our aim was to identify variables associated with either survival or progression (death/LT), based on an analysis of cases in the literature and our institution. A total of 137 cases (132 literature, 5 institutional) of HSV hepatitis were identified. The main features at clinical presentation were fever (98%), coagulopathy (84%), and encephalopathy (80%).

Resistance to combined ganciclovir and foscarnet therapy in a liver transplant recipient with possible dual‐strain cytomegalovirus coinfection

John Rodriguez, Katherine Casper, Gregory Smallwood, Andrei Stieber, Carlos Fasola, Jennifer Lehneman, Thomas Heffron – 27 September 2007 – We present a case report of a cytomegalovirus (CMV)‐seronegative, 58‐year‐old male who received a CMV‐seropositive donor liver transplant without CMV prophylaxis. On postoperative day 30, the patient developed primary CMV disease that responded to ganciclovir. On postoperative day 114, however, he was diagnosed with recurrent CMV infection.

Acute liver failure in Spain: Analysis of 267 cases

Àngels Escorsell, Antoni Mas, Manuel de la Mata, Spanish Group for the Study of Acute Liver Failure – 27 September 2007 – The cause of acute liver failure (ALF) is a major determinant of its outcome. Acetaminophen (paracetamol) overdose is a leading cause of ALF in some developed countries, whereas in others, such as Spain, it is extremely rare. To analyze the etiology, characteristics, and outcome of ALF in Spain, we performed a retrospective analysis of 267 patients whom we observed from 1992 to 2000.

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