Long‐term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti‐inflammatory effect
David R. Nelson, Zhengkun Tu, Consuelo Soldevila‐Pico, Manal Abdelmalek, Haizhen Zhu, Yi Ling Xu, Roniel Cabrera, Chen Liu, Gary L. Davis – 7 March 2007 – An imbalance in Th1 and Th2 cytokine production is implicated in disease progression of HCV. Our aim was to determine the effect of IL‐10 administration in patients with HCV‐related liver disease. Thirty patients with advanced fibrosis who had failed antiviral therapy were enrolled in a 12‐month treatment regimen with SQ IL‐10 given daily or thrice weekly. Liver biopsies were performed before and after therapy.