Notices
7 March 2007
Polycystic disease of the liver
Gregory T. Everson, Matthew R. G. Taylor, R. Brian Doctor – 7 March 2007 – Autosomal dominant polycystic disease is genetically heterogeneous with mutations in two distinct genes predisposing to the combination of renal and liver cysts (AD‐PKD1 and AD‐PKD2) and mutations in a third gene yielding isolated liver cysts (the polycystic liver disease gene). Transcription and translation of the PKD1 gene produces polycystin‐1, an integral membrane protein that may serve as an extracellular receptor.
PPARα in the pathogenesis of fatty liver disease
M. Sambasiva Rao, Janardan K. Reddy – 7 March 2007
Factors associated with fulminant liver failure during an outbreak among injection drug users with acute hepatitis B
Richard S. Garfein, William A. Bower, Cherry M. Loney, Yvan J. F. Hutin, Guo‐Liang Xia, Jaspaul Jawanda, Amy V. Groom, Omana V. Nainan, James S. Murphy, Beth P. Bell – 7 March 2007 – Death related to acute hepatitis B occurs in approximately 1% of patients. We investigated an outbreak of hepatitis B virus (HBV) infections among injection drug users (IDUs) resulting in several deaths. We conducted a case‐control study of fulminant (case patients) and nonfulminant (control patients) HBV infections. We directly sequenced the entire HBV genome from fulminant and nonfulminant cases.
Reduced oncotic necrosis in fas receptor‐deficient C57BL/6J‐lpr mice after bile duct ligation
Jaspreet S. Gujral, Jie Liu, Anwar Farhood, Hartmut Jaeschke – 7 March 2007 – Neutrophils aggravate cholestatic liver injury after bile duct ligation (BDL). Recently, it was suggested that hepatocellular apoptosis might be critical for liver injury in this model.
A better mousetrap
Adrian Reuben – 7 March 2007
Evolution of autoimmune hepatitis to primary sclerosing cholangitis: A sequential syndrome
Ayman A. Abdo, Vincent G. Bain, Krikor Kichian, Samuel S. Lee – 7 March 2007 – Recently, the autoimmune hepatitis (AIH)/primary sclerosing cholangitis (PSC) overlap syndrome has been reported increasingly. In this syndrome, patients present with features of both AIH and PSC. It has been suggested that the 2 diseases may be sequential in their occurrence, whereby patients have features of AIH and then after a number of years develop features of PSC, but clear confirmation of evolution has not been documented in adults.
Expression profiling of liver cell lines expressing entire or parts of hepatitis C virus open reading frame
Hideki Aizaki, Takashi Harada, Motoyuki Otsuka, Naohiko Seki, Mami Matsuda, Yue Wei Li, Hayato Kawakami, Yoshiharu Matsuura, Tatsuo Miyamura, Tetsuro Suzuki – 7 March 2007 – Although hepatitis C virus (HCV) is a causative agent of liver diseases, its mechanism of pathogenesis is still unclear, mainly because of the lack of adequate cell culture systems to support HCV infection and replication. In this report, we describe development and characterization of human hepatoma cell lines constitutively expressing entire (Hep394) or parts (Hep352, Hep3294) of the HCV open reading frame (ORF).
Extrahepatic manifestations of hepatitis C among United States male veterans
Hashem B. El‐Serag, Howard Hampel, Christine Yeh, Linda Rabeneck – 7 March 2007 – Hepatitis C virus (HCV) has been associated with several extrahepatic conditions. To date, most studies assessing these associations involved small numbers of patients and lacked a control group.
Dysregulation of glycogen synthase kinase‐3β signaling in hepatocellular carcinoma cells
Christèle Desbois‐Mouthon, Marie‐José Blivet‐Van Eggelpoë, Eléonore Beurel, Mathieu Boissan, Roland Delélo, Axelle Cadoret, Jacqueline Capeau – 7 March 2007 – It has been reported that upstream components of the insulin‐like growth factor (IGF) signaling axis could be overexpressed during hepatocarcinogenesis in humans and rodents. However, the signal transduction pathways activated downstream have been poorly studied.