Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases

Nathalie Ganne‐Carrié, Marianne Ziol, Victor de Ledinghen, Catherine Douvin, Patrick Marcellin, Laurent Castera, Daniel Dhumeaux, Jean‐Claude Trinchet, Michel Beaugrand – 28 November 2006 – A proper diagnosis of cirrhosis is essential for the management of patients with chronic liver diseases. We assessed the accuracy of liver stiffness measurement by Fibroscan for the diagnosis of cirrhosis in 1,257 patients with chronic liver diseases of various causes enrolled in a prospective multicenter study as well as clarified causes of discrepancies between liver histology and Fibroscan.

Serum amyloid A has antiviral activity against hepatitis C virus by inhibiting virus entry in a cell culture system

Muriel Lavie, Cécile Voisset, Ngoc Vu‐Dac, Virginie Zurawski, Gilles Duverlie, Czeslaw Wychowski, Jean Dubuisson – 28 November 2006 – Serum amyloid A (SAA) is an acute phase protein produced by the liver. SAA concentration increases markedly in the serum following inflammation and infection. Large increases in SAA concentration during the acute phase response suggest that SAA has a beneficial role in host defense.

Acute liver failure induced by green tea extracts: Case report and review of the literature

Michele Molinari, Kymberly D.S. Watt, Thomas Kruszyna, Rebecca Nelson, Mark Walsh, Weei‐Yuan Huang, Bjorn Nashan, Kevork Peltekian – 28 November 2006 – In industrialized countries, over‐the‐counter dietary supplements have become popular in preventing and treating an expanding list of medical conditions. Although most commercially available supplements have not been rigorously tested for safety and efficacy, they have found an enlarging market because they are considered natural.

Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: A cross validated retrospective assessment

Claudia O. Zein, Kristi Beatty, Anthony B. Post, Laurie Logan, Sara Debanne, Arthur J. McCullough – 28 November 2006 – An epidemiological association between cigarette smoking and primary biliary cirrhosis (PBC) has been demonstrated. Our aim was to determine the relationship between smoking and severity of liver fibrosis at presentation in patients with PBC. All patients with PBC seen at the three major teaching hospitals of Case Western Reserve University between October 1998 and December 2005 were identified.

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