Michal Abel, Damien Sène, Stanislas Pol, Marc Bourlière, Thierry Poynard, Frédéric Charlotte, Patrice Cacoub, Sophie Caillat‐Zucman – 28 November 2006 – CD8 T cell killing of hepatitis C virus (HCV)‐infected hepatocytes is thought to contribute to liver damage during chronic HCV infection, whereas the participation of HCV‐nonspecific immune cells is unclear.
Fabien Zoulim – 28 November 2006
Pantxika Bellecave, Darius Moradpour – 28 November 2006 – Protein synthesis in mammalian cells requires initiation factor eIF3, a ∼750‐kilodalton complex that controls assembly of 40S ribosomal subunits on messenger RNAs (mRNAs) bearing either a 5′‐cap or an internal ribosome entry site (IRES). Cryoelectron microscopy reconstructions show that eIF3, a five‐lobed particle, interacts with the hepatitis C virus (HCV) IRES RNA and the 5′‐cap binding complex eIF4F via the same domain.
Jayant A. Talwalkar – 28 November 2006
Yesim Erim, Mingo Beckmann, Camino Valentin‐Gamazo, Massimo Malago, Andrea Frilling, Joerg F. Schlaak, Guido Gerken, Christoph E. Broelsch, Wolfgang Senf – 28 November 2006 – We investigated the psychosocial effects of a right hepatectomy on donors for adult living donor liver transplantation (ALDLT). Questionnaires were sent to 66 actual donors, who had undergone ALDLT between August 1998 and September 2003, as well as to 139 potential donors, who had been examined as possible candidates for ALDLT; the latter had been excluded and had not undergone surgery.
Ewa Brojer, Piotr Grabarczyk, Grzegorz Liszewski, Maria Mikulska, Jean‐Pierre Allain, Magdalena Letowska, Polish Blood Transfusion Service Viral Study Group – 28 November 2006 – Nucleic acid testing (NAT) for hepatitis B virus (HBV) has been performed in Poland since 2005 on samples seronegative for hepatitis B surface antigen (HBsAg), anti–hepatitis C virus (anti‐HCV), and anti–human immunodeficiency virus (anti‐HIV). Tools included 24‐donation pool testing (PT) using Cobas Amplicor or in individual donations (ID) by Procleix Ultrio.
Won‐Il Jeong, Ogyi Park, Svetlana Radaeva, Bin Gao – 28 November 2006 – Liver fibrosis, a common scarring response to chronic liver injury, is a precursor to cirrhosis and liver cancer. Here, we identified signal transducer and activator of transcription 1 (STAT1) as an important negative regulator in liver fibrosis. Our findings show that disruption of the STAT1 gene accelerated liver fibrosis and hepatic stellate cell (HSC) proliferation in an in vivo model of carbon tetrachloride (CCl4)‐induced liver fibrosis.
Richard J. Colonno, Ronald Rose, Carl J. Baldick, Steven Levine, Kevin Pokornowski, Cheng F. Yu, Ann Walsh, Jie Fang, Mayla Hsu, Charles Mazzucco, Betsy Eggers, Sharon Zhang, Mary Plym, Kenneth Klesczewski, Daniel J. Tenney – 28 November 2006 – Comprehensive monitoring of genotypic and phenotypic antiviral resistance was performed on 673 entecavir (ETV)‐treated nucleoside naïve hepatitis B virus (HBV) patients. ETV reduced HBV DNA levels to undetectable by PCR (<300 copies/mL, <57 IU/mL) in 91% of hepatitis B e antigen (HBeAg)‐positive and ‐negative patients by Week 96.
Massimo Primignani, Giovanni Barosi, Gaetano Bergamaschi, Umberto Gianelli, Federica Fabris, Raffaella Reati, Alessandra Dell'Era, Paolo Bucciarelli, Pier Mannuccio Mannucci – 28 November 2006 – The diagnosis of an underlying chronic myeloproliferative disorder (CMPD) is often problematic in patients with primary extrahepatic portal vein obstruction (EHPVO) or Budd‐Chiari syndrome (BCS); indeed, conventional clinical and hematological parameters usually yield insufficient information.
David E. Cohen – 28 November 2006