Sphingosine 1‐phosphate protects rat liver sinusoidal endothelial cells from ethanol‐induced apoptosis: Role of intracellular calcium and nitric oxide

Dong‐Mei Zheng, Tsuneo Kitamura, Kenichi Ikejima, Nobuyuki Enomoto, Shunhei Yamashina, Satoko Suzuki, Yoshiyuki Takei, Nobuhiro Sato – 20 October 2006 – In alcoholic liver disease, ethanol‐induced damage to sinusoidal endothelial cells (SECs) appears to be important in the progression of liver damage. However, little is known about the mechanisms responsible for protection of SECs against ethanol‐induced injury.

Loss of IL‐7 receptor alpha‐chain (CD127) expression in acute HCV infection associated with viral persistence

Lucy Golden‐Mason, James R. Burton, Nicole Castelblanco, Jared Klarquist, Salvador Benlloch, Chia Wang, Hugo R. Rosen – 20 October 2006 – Interleukin‐7 (IL‐7) is required for the establishment and maintenance of memory CD4+ and CD8+ T lymphocytes, and cells lacking IL‐7Rα (CD127) demonstrate impaired IL‐2 secretion and have a short life‐span. Chronic HCV is characterized by T cells that are functionally impaired and exhibit an immature phenotype.

A simple noninvasive index for predicting long‐term outcome of chronic hepatitis C after interferon‐based therapy

Ming‐Lung Yu, Shi‐Ming Lin, Chuan‐Mo Lee, Chia‐Yen Dai, Wen‐Yu Chang, Shinn‐Cherng Chen, Li‐Po Lee, Zu‐Yau Lin, Ming‐Yuh Hsieh, Liang‐Yen Wang, Wan‐Long Chuang, Yun‐Fan Liaw – 20 October 2006 – Changes in hepatic fibrosis after interferon‐based therapy may be important in determining the long‐term outcome of chronic hepatitis C (CHC). The use of liver biopsy for posttreatment assessment is not a viable option as a routine follow‐up procedure.

Successful salvage therapy with tigecycline after linezolid failure in a liver transplant recipient with MRSA pneumonia

Fuat H. Saner, Matthias Heuer, Peter‐Michael Rath, Julia Gensicke, Arnold Radtke, Nina Drühe, Eva‐Marija Rüngeler, Silvio Nadalin, Massimo Malagó, Christoph E. Broelsch – 20 October 2006 – Pulmonary infections are a significant cause of morbidity and mortality after liver transplantation. Infections with methicillin‐resistant Staphylococcus aureus (MRSA) have increased in the last 10 years. Mortality may exceed 80% in liver transplant recipients who develop MRSA pneumonia.

Bullous pemphigoid after liver transplantation for liver failure

Nanda Kerkar, Steven Cohen, Christina Dugan, Raffaella A. Morotti, Robert G. Phelps, Betsy Herold, Benjamin Shneider, Sukru Emre – 20 October 2006 – Coomb's positive autoimmune hemolytic anemia with giant cell hepatitis (GCH) is a rare cause of liver failure and is usually associated with poor prognosis. A child with liver kidney microsomal (LKM) antibody positivity underwent successful liver transplantation for liver failure secondary to GCH with Coomb's positive hemolytic anemia. Autoimmune neutropenia developed ten months after transplant.

Impaired erythropoietin production in liver transplant recipients: The role of calcineurin inhibitors

Valérie Bardet, Alcindo Pissaia Junior, Joël Coste, Carinne Lecoq‐Lafon, Sandrine Chouzenoux, Denis Bernard, Olivier Soubrane, Catherine Lacombe, Yvon Calmus, Filoména Conti – 20 October 2006 – Anemia is common following liver transplantation. Because cyclosporine inhibits erythropoietin (Epo) production in experimental models, we investigated whether Epo production was impaired in liver transplant recipients receiving a cyclosporine‐ or tacrolimus‐based immunosuppressive regimen.

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