Thrombolysis for early hepatic artery thrombosis: Definitive therapy or diagnostic aid?

James D. Perkins – 30 May 2007 – Hepatic artery thrombosis is an uncommon complication of liver transplantation. However, it is a major indication for re‐transplantation. The use of transcatheter thrombolysis and subsequent surgical revascularization as a graft salvage procedure is discussed. Four of 5 cases (80%) were successful in re‐establishing flow and uncovering underlying arterial anatomic defects. None were treated definitively by endoluminal measures due to an inability to resolve the underlying anatomic defects.

Rapidly progressive recurrent hepatitis C virus infection starting 9 days after liver transplantation

Neeraj Saraf, M. Isabel Fiel, Graciela DeBoccardo, Sukru Emre, Thomas D. Schiano – 30 May 2007 – Early histological recurrence of hepatitis C after liver transplantation (LT) has a negative impact on patient and graft survival. We report a case of histological recurrence of HCV occurring in the second week after LT. A 75‐year‐old woman with chronic HCV and hepatocellular carcinoma underwent LT with an organ from a 75‐year‐old HCV‐negative deceased donor.

Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell–mediated liver regeneration

Peter Jelnes, Eric Santoni‐Rugiu, Morten Rasmussen, Susanne Lunøe Friis, Jens Høiriis Nielsen, Niels Tygstrup, Hanne Cathrine Bisgaard – 30 May 2007 – The experimental protocols used in the investigation of stem cell–mediated liver regeneration in rodents are characterized by activation of the hepatic stem cell compartment in the canals of Hering followed by transit amplification of oval cells and their subsequent differentiation along hepatic lineages.

Hepatitis B viral load predicts survival of HCC patients undergoing systemic chemotherapy

Winnie Yeo, Frankie K. F. Mo, Stephen L. Chan, Nancy W. Y. Leung, Pun Hui, Wai‐Yip Lam, Tony S. K. Mok, Kowk C. Lam, Wing M. Ho, Jane Koh, Julian W. Tang, Anthony T. Chan, Paul K. S. Chan – 30 May 2007 – HCC is a common cause of morbidity and mortality. For patients who are not candidates for curative surgery, systemic chemotherapy is one of the standard treatments. In parts of China and the Far East, over 80% of HCC patients have chronic HBV infection. In this study, we aimed to assess the relationship between pre‐chemotherapy HBV viral load and the survival of HCC patients.

Hepatitis B x antigen up‐regulates vascular endothelial growth factor receptor 3 in hepatocarcinogenesis

Zhaorui Lian, Jie Liu, Mengchao Wu, Hong‐Yang Wang, Patrick Arbuthnot, Michael Kew, Mark A. Feitelson – 30 May 2007 – Hepatitis B x antigen (HBxAg) is a trans‐activating protein that contributes to liver cancer, in part, by altering the expression of cellular genes. However, few natural effectors of HBxAg have been identified. Hence, HBxAg positive and negative HepG2 cells were prepared and analyzed by PCR select cDNA subtraction.

Survival outcomes in liver transplantation for hepatocellular carcinoma, comparing impact of hepatitis C versus other etiology of cirrhosis

Adel Bozorgzadeh, Mark Orloff, Peter Abt, Georgios Tsoulfas, Durald Younan, Randeep Kashyap, Ashok Jain, Parvez Mantry, Benedict Maliakkal, Alok Khorana, Seymour Schwartz – 30 May 2007 – The incidence of hepatocellular carcinoma (HCC) is on the rise worldwide as the most common primary hepatic malignancy. In the US approximately one half of all HCC is related to Hepatitis C virus (HCV) infection. The relationship between the primary disease and HCC recurrence after liver transplantation is unknown.

Does middle hepatic vein omission in a right split graft affect the outcome of liver transplantation? A comparative study of right split livers with and without the middle hepatic vein

Mustapha Adham, Jérôme Dumortier, Amr Abdelaal, Pierre Sagnard, Catherine Boucaud, Olivier Boillot – 30 May 2007 – Preservation of the middle hepatic vein (MHV) for a right split liver transplantation (SLT) in an adult recipient is still controversial. The aim of this study was to evaluate the graft and patient outcomes after liver transplantation (LT) using a right split graft, according to the type of venous drainage. From February 2000 to May 2006, 33 patients received 34 cadaveric right split liver grafts.

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