Hugo E. Vargas – 18 October 2006 – Key Concepts: 1The immediate postoperative concerns in a patient with primary sclerosing cholangitis.2Recognize the difficulties in assessing biliary health in patients that have had complicated postoperative biliary concerns.3Recognize the difficulty in ascertaining the presence of chronic rejection vs. recurrent primary sclerosing cholangitis. Liver Transpl. 12:S65–S67. 2006. © 2006 AASLD.
Fredric Gordon – 18 October 2006 – Key Concepts: 1Primary sclerosing cholangitis (PSC) in the nontransplant setting is a chronic, progressive liver disease characterized by diffuse stricturing of the biliary tree, cholestatic liver enzymes, and a compatible liver biopsy.2Cholangiography reveals irregularity of the bile duct wall, strictures, beading, and diverticula.3The typical biopsy reveals inflammation and fibrosis of the interlobular and septal bile ducts, often with obliteration or biliary‐type cirrhosis.4The precise pathogenetic mechanism remains elusive but is assumed to be an autoi
Patrick S. Kamath – 18 October 2006 – Key Concepts: 1Diagnosis of Budd‐Chiari syndrome can be made on the basis of radiological imaging alone without the need for liver biopsy.2Ultrasonography, computed tomography, and magnetic resonance imaging all show various degrees of occlusion of the hepatic veins and/or inferior vena cava. Hypertrophy of the caudate lobe may also be seen.3Computed tomographic and magnetic resonance imaging give a better idea of hepatic perfusion.
James R. Burton, Hugo R.
Richard B. Freeman – 18 October 2006 – Key Concepts: 1Liver transplantation offers excellent results for selected candidates with hepatocellular carcinoma (HCC).2Selection strategies have evolved but are mainly based on size and number of tumors, which are surrogates for vascular invasion.
Manjushree Gautam, Rekha Cheruvattath, Vijayan Balan – 9 October 2006 – Recurrence of autoimmune liver disease in allografts has long been a topic of debate. We conducted a systematic review of the literature to examine the reported incidence of recurrence after liver transplantation of primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH). The MEDLINE, EMBASE, and Cochrane electronic databases were used to identify articles.
Thomas Gerhardt, Uwe Pöge, Birgit Stoffel‐Wagner, Manuela Ahrendt, Martin Wolff, Ulrich Spengler, Holger Palmedo, Tilman Sauerbruch, Rainer P. Woitas – 9 October 2006 – Early detection of renal dysfunction in patients after orthotopic liver transplantation is important. Creatinine‐based equations to estimate glomerular filtration rate (GFR) were found to be less accurate in liver transplant recipients than in their original populations.
Kassiani Theodoraki, Nikolaos Arkadopoulos, George Fragulidis, Dionysios Voros, Konstantinos Karapanos, Maria Markatou, Georgia Kostopanagiotou, Vassilios Smyrniotis – 9 October 2006 – Hepatectomies performed under selective hepatic vascular exclusion are associated with a series of events culminating in ischemia/reperfusion injury, a state that shares common characteristics with situations known to result in global or regional hyperlactatemia.
Gero Puhl, Peter Olschewski, Wenzel Schöning, Gerhard Hunold, Hans‐Georg Liesaus, Robert Winkler, Ulf P. Neumann, Thomas E.O. Schubert, Volker Schmitz, Peter Neuhaus – 9 October 2006 – Adequate flushing for liver donation requires large fluid volumes delivered at a high flow. This can be achieved more effectively with crystalloid solutions than with colloid‐based solutions. This study examined the combination of initial histidine‐tryptophan‐ketoglutarate solution (HTK) graft flush and subsequent storage in University of Wisconsin solution (UW) to that of the single use of each solution.