Fluordeoxyglucose positron emission tomography contributes to management of pediatric liver transplantation candidates with fever of unknown origin

Ekkehard Sturm, Edmond H.H.M. Rings, Elisabeth H. Schölvinck, Annette S.H. Gouw, Robert J. Porte, Jan Pruim – 20 October 2006 – Fever of unknown origin (FUO) frequently complicates the management of pediatric patients with terminal chronic liver failure during the pretransplantation period and may lead to increased morbidity and mortality. Nonhepatic origins of systemic infections may render the patient unsuitable for transplantation whereas infections within the liver may require organ resection for a cure.

Plasma cholesterol is hyperresponsive to statin in ABCG5/ABCG8 transgenic mice

Weiqing Tang, Yinyan Ma, Liqing Yu – 20 October 2006 – Interindividual variation exists in response to statin therapy. It has been hypothesized that subjects with higher baseline cholesterol synthesis rates are more sensitive to statins. To directly test this hypothesis, mice overexpressing the heterodimeric ATP‐binding cassette (ABC) transporter G5/G8 (G5G8Tg mice) were treated with lovastatin because they have a compensatory increase in cholesterol biosynthesis as a result of increased cholesterol excretion into bile and feces.

Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas

Yoh Zen, Takahiko Fujii, Keita Itatsu, Koichi Nakamura, Hiroshi Minato, Satomi Kasashima, Hiroshi Kurumaya, Kazuyoshi Katayanagi, Atsuhiro Kawashima, Shinji Masuda, Hideki Niwa, Takeshi Mitsui, Yasuyuki Asada, Shouji Miura, Tetsuo Ohta, Yasuni Nakanuma – 20 October 2006 – Recently, attention has been drawn to papillary neoplasm of the pancreatobiliary systems. In the pancreas, the disease entity of intraductal papillary mucinous neoplasm (IPMN‐P) is widely recognized.

T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells

Alessandra Warren, David G. Le Couteur, Robin Fraser, David G. Bowen, Geoffrey W. McCaughan, Patrick Bertolino – 20 October 2006 – The liver has an established ability to induce tolerance. Recent evidence indicates that this unique property might be related to its distinctive architecture allowing T cells to be activated in situ independently of lymphoid tissues.

Impaired erythropoietin production in liver transplant recipients: The role of calcineurin inhibitors

Valérie Bardet, Alcindo Pissaia Junior, Joël Coste, Carinne Lecoq‐Lafon, Sandrine Chouzenoux, Denis Bernard, Olivier Soubrane, Catherine Lacombe, Yvon Calmus, Filoména Conti – 20 October 2006 – Anemia is common following liver transplantation. Because cyclosporine inhibits erythropoietin (Epo) production in experimental models, we investigated whether Epo production was impaired in liver transplant recipients receiving a cyclosporine‐ or tacrolimus‐based immunosuppressive regimen.

Bullous pemphigoid after liver transplantation for liver failure

Nanda Kerkar, Steven Cohen, Christina Dugan, Raffaella A. Morotti, Robert G. Phelps, Betsy Herold, Benjamin Shneider, Sukru Emre – 20 October 2006 – Coomb's positive autoimmune hemolytic anemia with giant cell hepatitis (GCH) is a rare cause of liver failure and is usually associated with poor prognosis. A child with liver kidney microsomal (LKM) antibody positivity underwent successful liver transplantation for liver failure secondary to GCH with Coomb's positive hemolytic anemia. Autoimmune neutropenia developed ten months after transplant.

Subscribe to