Early recurrence of hepatitis C virus infection after liver transplantation

Lydia M. Petrovic – 18 October 2006 – Key Concepts: 1Early recurrence of hepatitis C is universal.2Typical histopathologic features of hepatitis C virus (HCV) and acute allograft rejection (AAR) exist.3Early recurrent HCV may be differentiated from AAR.4Liver biopsy plays a role in diagnosing HCV and AAR.5Risk factors for recurrent HCV should be known.6The natural history of recurrent HCV should be known.7The future role of ancillary studies beyond liver biopsy is assessed. Liver Transpl 12:S32–S37, 2006. © 2006 AASLD.

A difficult case of primary sclerosing cholangitis

Hugo E. Vargas – 18 October 2006 – Key Concepts: 1The immediate postoperative concerns in a patient with primary sclerosing cholangitis.2Recognize the difficulties in assessing biliary health in patients that have had complicated postoperative biliary concerns.3Recognize the difficulty in ascertaining the presence of chronic rejection vs. recurrent primary sclerosing cholangitis. Liver Transpl. 12:S65–S67. 2006. © 2006 AASLD.

Recurrent primary sclerosing cholangitis: Clinical diagnosis and long‐term management issues

Fredric Gordon – 18 October 2006 – Key Concepts: 1Primary sclerosing cholangitis (PSC) in the nontransplant setting is a chronic, progressive liver disease characterized by diffuse stricturing of the biliary tree, cholestatic liver enzymes, and a compatible liver biopsy.2Cholangiography reveals irregularity of the bile duct wall, strictures, beading, and diverticula.3The typical biopsy reveals inflammation and fibrosis of the interlobular and septal bile ducts, often with obliteration or biliary‐type cirrhosis.4The precise pathogenetic mechanism remains elusive but is assumed to be an autoi

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