IL‐2 receptor α−/− mice and the development of primary biliary cirrhosis

Kanji Wakabayashi, Zhe‐Xiong Lian, Yuki Moritoki, Ruth Y. Lan, Koichi Tsuneyama, Ya‐Hui Chuang, Guo‐Xiang Yang, William Ridgway, Yoshiyuki Ueno, Aftab A. Ansari, Ross L. Coppel, Ian R. Mackay, M. Eric Gershwin – 20 October 2006 – Recently, we identified a child born with a genetic deficiency of IL‐2 receptor α (IL‐2Rα, CD25) expression who had several clinical manifestations of primary biliary cirrhosis (PBC).

Fatal GvHD as a complication of liver transplantation for undetermined fulminant hepatic failure and associated aplastic anemia

Michela G. Schäppi, Dominique C. Belli, Peter C. Rimensberger, Christophe Chardot, Gürkan Kaya, Jean‐Marie Tiercy, Hulya Ozsahin – 20 October 2006 – Fulminant hepatic failure of unknown origin is the most common cause of fulminant hepatitis with high incidence of aplastic anaemia. Furthermore, the association of liver failure and aplastic anaemia has an increased mortality rate. In this report we describe a 16‐month‐old boy who presented with aplastic anaemia preceding a non‐A, non‐B, non‐C fulminant liver failure.

Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis

Pierre J. Zindy, Annie L'Helgoualc'h, Dominique Bonnier, Antony Le Béchec, Katia Bourd‐Boitin, Chang Xian Zhang, Orlando Musso, Denise Glaise, Marie Bérangère Troadec, Olivier Loréal, Bruno Turlin, Jean Léger, Bruno Clément, Nathalie Théret – 20 October 2006 – The molecular mechanisms underlying the progression of cirrhosis toward hepatocellular carcinoma were investigated by a combination of DNA microarray analysis and literature data mining.

Fluordeoxyglucose positron emission tomography contributes to management of pediatric liver transplantation candidates with fever of unknown origin

Ekkehard Sturm, Edmond H.H.M. Rings, Elisabeth H. Schölvinck, Annette S.H. Gouw, Robert J. Porte, Jan Pruim – 20 October 2006 – Fever of unknown origin (FUO) frequently complicates the management of pediatric patients with terminal chronic liver failure during the pretransplantation period and may lead to increased morbidity and mortality. Nonhepatic origins of systemic infections may render the patient unsuitable for transplantation whereas infections within the liver may require organ resection for a cure.

Plasma cholesterol is hyperresponsive to statin in ABCG5/ABCG8 transgenic mice

Weiqing Tang, Yinyan Ma, Liqing Yu – 20 October 2006 – Interindividual variation exists in response to statin therapy. It has been hypothesized that subjects with higher baseline cholesterol synthesis rates are more sensitive to statins. To directly test this hypothesis, mice overexpressing the heterodimeric ATP‐binding cassette (ABC) transporter G5/G8 (G5G8Tg mice) were treated with lovastatin because they have a compensatory increase in cholesterol biosynthesis as a result of increased cholesterol excretion into bile and feces.

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