Treating hepatitis C infection in liver transplant recipients

Norah A. Terrault, Marina Berenguer – 25 July 2006 – Chronic infection with hepatitis C virus (HCV) is a growing problem worldwide, with up to 300 million individuals infected, and those with chronic infection are at risk for cirrhosis and hepatocellular carcinoma. HCV infection is the most common indication for liver transplantation in the United States and Europe. Unfortunately, although transplantation is effective for treating decompensated cirrhosis and limited hepatocellular carcinoma associated with hepatitis C, HCV reinfection is virtually the rule among transplant recipients.

Pulmonary hypertension after liver transplantation in patients with antecedent hepatopulmonary syndrome: A report of 2 cases and review of the literature

Federico Aucejo, Charles Miller, David Vogt, Bijan Eghtesad, Shunichi Nakagawa, James K. Stoller – 25 July 2006 – Hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PPHTN) are distinct clinical entities that may complicate liver disease. Although HPS and PPHTN are different, several reports describe 6 patients in whom both conditions have occurred, either concurrently or sequentially, sometimes with the onset of PPHTN after liver transplantation.

Psychosocial aspects of pediatric living donor liver transplantation

Sylvia Kroencke, Christian Wilms, Dieter Broering, Xavier Rogiers, Karl‐Heinz Schulz – 12 July 2006 – While the medical aspects of living donor liver transplantation (LDLT) have been investigated to a comparatively large degree, only in recent years have psychosocial aspects like donors' quality of life and attitude towards living donation been dealt with. In the course of a retrospective study, we examined 36 pediatric living liver donors at an average of 4.5 ± 2.8 years postoperatively.

Analysis of renal function in the immediate postoperative period after partial liver transplantation

Luis Gajate, Ascensión Martín, Elena Elías, Maria T Tenorio, Angélica de Pablo, Cristina Carrasco, Adolfo Martínez, Angel Candela, Javier Zamora, Fernando Liaño – 12 July 2006 – Although renal dysfunction is common after liver transplantation, postoperative renal function after split liver transplantation (SLT) has not been well studied. Renal function immediately after surgery was analyzed retrospectively in 16 patients that received a SLT (SLT group).

Response to transarterial chemoembolization as a biological selection criterion for liver transplantation in hepatocellular carcinoma

Gerd Otto, Sascha Herber, Michael Heise, Ansgar W. Lohse, Christian Mönch, Fernando Bittinger, Maria Hoppe‐Lotichius, Marcus Schuchmann, Anja Victor, Michael Pitton – 6 July 2006 – Criteria to select patients with hepatocellular carcinoma (HCC) for liver transplantation (LT) are based on tumor size and number of nodules rather than on tumor biology. The present study was undertaken to assess the role of transarterial chemoembolization (TACE) in selecting patients with tumors suitable for LT.

Transient elastography for diagnosis of advanced fibrosis and portal hypertension in patients with hepatitis C recurrence after liver transplantation

Jose A. Carrión, Miquel Navasa, Jaume Bosch, Miquel Bruguera, Rosa Gilabert, Xavier Forns – 5 July 2006 – Recurrence of hepatitis C after liver transplantation (LT) is the main cause of graft loss and retransplantation. Frequent liver biopsies are essential to follow‐up hepatitis C virus (HCV)–induced liver damage. However, liver biopsy is an invasive and expensive procedure. We evaluated prospectively the diagnostic accuracy of noninvasive measurement of liver stiffness (by transient elastography) to assess the severity of hepatitis C recurrence after LT.

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