Reversibility of hepatic fibrosis in treated genetic hemochromatosis: A study of 36 cases

Ludivine Falize, Anne Guillygomarc'h, Michele Perrin, Fabrice Lainé, Dominique Guyader, Pierre Brissot, Bruno Turlin, Yves Deugnier – 26 July 2006 – The current study was undertaken to assess whether fibrosis could regress under venesection therapy in patients with C282Y homozygous genetic hemochromatosis. The 36 patients studied were recruited from a subfile of our database consisting of 125 C282Y homozygotes with either severe fibrosis or cirrhosis (F3 or F4 fibrosis stage, respectively, according to the METAVIR grading system).

Induction immunosuppression with rabbit antithymocyte globulin in pediatric liver transplantation

Ashesh Shah, Avinash Agarwal, Richard Mangus, Joel Lim, Jonathan Fridell, Rodrigo Vianna, A. Joseph Tector – 25 July 2006 – Routine use of rabbit antithymocyte globulin (RATG) induction therapy remains controversial in pediatric liver transplantation. We reviewed our experience of 18 cadaveric liver transplants in 18 children over a span of 2 years. All patients received the same immunosuppression: perioperative steroid therapy with taper, 3 doses of RATG, and maintenance therapy of steroids and tacrolimus started on postoperative day 3. Mean follow‐up was 2.2 ± 0.2 years.

Clinical reactivation after liver transplantation with an unusual minor strain of hepatitis B virus in an occult carrier

Bernhard Zöllner, Heinz‐Hubert Feucht, Martina Sterneck, Hansjörg Schäfer, Xavier Rogiers, Lutz Fischer – 25 July 2006 – Hepatitis B virus (HBV) DNA is detectable in a number of liver transplant candidates who are negative for hepatitis B surface antigen (HBsAg). After liver transplantation (LT), such patients may have molecular and/or serologic evidence of HBV replication. However, clinical disease from reactivation of occult HBV infection after LT has not been described.

Disseminated coccidioidomycosis in a liver transplant recipient with negative serology: Use of polymerase chain reaction

Maha A. Assi, Matthew J. Binnicker, Nancy L. Wengenack, Paul J. Deziel, Andrew D. Badley – 25 July 2006 – Coccidioidomycosis has been previously described in recipients of solid organ transplantation, especially in patients who have lived in or have visited areas endemic for Coccidioides spp. We present a case of coccidioidomycosis in a liver transplant recipient with several unique aspects, including negative serology and positive polymerase chain reaction results. Liver Transpl 12:1290–1292, 2006. © 2006 AASLD.

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