Christine Rollier, Joost A. R. Drexhage, Babs E. Verstrepen, Ernst J. Verschoor, Ronald E. Bontrop, Gerrit Koopman, Jonathan L. Heeney – 7 March 2007 – Chronic hepatitis C virus (HCV) infection in humans is associated with an impairment of dendritic cells (DC). It has been hypothesized that impairment of DC function may be a central mechanism facilitating the establishment of a chronic carrier state.

Brent A. Neuschwander‐Tetri, Elizabeth M. Brunt, Kent R. Wehmeier, Dana Oliver, Bruce R. Bacon – 7 March 2007 – Insulin resistance (IR) commonly is associated with nonalcoholic steatohepatitis (NASH). To establish whether IR causes NASH, this study was undertaken to determine if improving IR would improve the histologic features that define NASH. Thirty adults with prior biopsy evidence of NASH were enrolled to receive rosiglitazone, 4 mg twice daily for 48 weeks.

Ruth F. Itzhaki, William L. Irving, Matthew A. Wozniak – 7 March 2007

Jay H. Hoofnagle – 7 March 2007

Eduardo Fassio, Estela Álvarez, Nora Domínguez, Graciela Landeira, Cristina Longo – 7 March 2007 – Nonalcoholic steatohepatitis may cause severe fibrosis, cirrhosis, and hepatocellular carcinoma, but supporting evidence is based on indirect data. Few publications have examined the results of repeat liver biopsies to evaluate progression of fibrosis. The aims of this study were to assess rate of fibrosis progression in untreated patients with nonalcoholic steatohepatitis and to identify associated variables.

Kenichi Harada, Kazuo Ohba, Satoru Ozaki, Kumiko Isse, Toshiya Hirayama, Akihiro Wada, Yasuni Nakanuma – 7 March 2007 – Human beta‐defensins (hBDs) are important antimicrobial peptides that contribute to innate immunity at mucosal surfaces. This study was undertaken to investigate the expression of hBD‐1 and hBD‐2 in intrahepatic biliary epithelial cells in specimens of human liver, and 4 cultured cell lines (2 consisting of biliary epithelial cells and 2 cholangiocarcinoma cells). In addition, hBD‐1 and hBD‐2 were assayed in specimens of bile.

Nobuyoshi Fukushima, Greg Nalbandian, Judy Van De Water, Kandra White, Aftab A. Ansari, Patrick Leung, Thomas Kenny, Shizuo G. Kamita, Bruce D. Hammock, Ross L. Coppel, Freida Stevenson, Hiromi Ishibashi, M. Eric Gershwin – 7 March 2007 – Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of autoantibodies to mitochondria (AMA). Recent evidence suggests that PBC develops after a locally driven response in the mucosa, where immunoglobulin A (IgA) is the dominant antibody isotype.

Harvey J. Alter – 7 March 2007

Odette Viñas, Ramón Bataller, Pau Sancho‐Bru, Pere Ginès, Cristina Berenguer, Carlos Enrich, Josep M. Nicolás, Guadalupe Ercilla, Teresa Gallart, Jordi Vives, Vicente Arroyo, Juan Rodés – 7 March 2007 – Following cell activation, hepatic stellate cells (HSCs) acquire proinflammatory and profibrogenic properties. We investigated whether activated HSCs also display immune properties.

Michael D. Chipchase, Mary O'Neill, David W. Melton – 7 March 2007 – ERCC1‐XPF is the endonuclease that cuts 5′ of the damage in nucleotide excision repair (NER). Unlike other NER proteins, ERCC1‐XPF is also involved in recombination and the repair of DNA interstrand cross‐links. Unique among the NER gene knockouts, Ercc1 null mice are severely runted with high levels of hepatocyte polyploidy. To understand the link between DNA repair deficiency and polyploidy we have compared the premature polyploidy in Ercc1 null liver with the normal development of polyploidy in aging control mice.