Chih‐Te Wu, Jason P. Eiserich, Aftab A. Ansari, Ross L. Coppel, Sripriya Balasubramanian, Christopher L. Bowlus, M. Eric Gershwin, Judy Van De Water – 7 March 2007 – Previous studies have suggested that increased nitric oxide (NO)‐mediated products are found in the livers of subjects with primary biliary cirrhosis (PBC), but the mechanisms involved remain enigmatic.

Giovan Giuseppe Di Costanzo, Manuel Rodríguez, Rosario F. Velázquez – 7 March 2007

Dimitrios Tsikas, Iris Rode, Thomas Becker, Björn Nashan, Jürgen Klempnauer, Jürgen C. Frölich – 7 March 2007

7 March 2007

Gregory T. Everson, Matthew R. G. Taylor, R. Brian Doctor – 7 March 2007 – Autosomal dominant polycystic disease is genetically heterogeneous with mutations in two distinct genes predisposing to the combination of renal and liver cysts (AD‐PKD1 and AD‐PKD2) and mutations in a third gene yielding isolated liver cysts (the polycystic liver disease gene). Transcription and translation of the PKD1 gene produces polycystin‐1, an integral membrane protein that may serve as an extracellular receptor.

M. Sambasiva Rao, Janardan K. Reddy – 7 March 2007

Richard S. Garfein, William A. Bower, Cherry M. Loney, Yvan J. F. Hutin, Guo‐Liang Xia, Jaspaul Jawanda, Amy V. Groom, Omana V. Nainan, James S. Murphy, Beth P. Bell – 7 March 2007 – Death related to acute hepatitis B occurs in approximately 1% of patients. We investigated an outbreak of hepatitis B virus (HBV) infections among injection drug users (IDUs) resulting in several deaths. We conducted a case‐control study of fulminant (case patients) and nonfulminant (control patients) HBV infections. We directly sequenced the entire HBV genome from fulminant and nonfulminant cases.

Jaspreet S. Gujral, Jie Liu, Anwar Farhood, Hartmut Jaeschke – 7 March 2007 – Neutrophils aggravate cholestatic liver injury after bile duct ligation (BDL). Recently, it was suggested that hepatocellular apoptosis might be critical for liver injury in this model.

Adrian Reuben – 7 March 2007

Ayman A. Abdo, Vincent G. Bain, Krikor Kichian, Samuel S. Lee – 7 March 2007 – Recently, the autoimmune hepatitis (AIH)/primary sclerosing cholangitis (PSC) overlap syndrome has been reported increasingly. In this syndrome, patients present with features of both AIH and PSC. It has been suggested that the 2 diseases may be sequential in their occurrence, whereby patients have features of AIH and then after a number of years develop features of PSC, but clear confirmation of evolution has not been documented in adults.