Multiple polymorphic loci determine basal hepatic and splenic iron status in mice

Gemma R. Grant, Susan W. Robinson, Richard E. Edwards, Bruce Clothier, Reginald Davies, David J. Judah, Karl W. Broman, Andrew G. Smith – 23 June 2006 – Polymorphisms of genes linked to iron metabolism may account for individual variability in hemochromatosis and iron status connected with liver and cardiovascular diseases, cancers, toxicity, and infection. Mouse strains exhibit marked differences in levels of non‐heme iron, with C57BL/6J and SWR showing low and high levels, respectively.

A double‐blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg‐positive chronic hepatitis B

MinDe Zeng, YiMin Mao, GuangBi Yao, Hao Wang, JinLin Hou, YaoZong Wang, Beulah N. Ji, Chai‐Ni P. Chang, Keith F. Barker – 23 June 2006 – Four hundred and eighty Chinese subjects with hepatitis B e antigen (HBeAg)–positive chronic hepatitis B (CHB) were enrolled in a multicenter, double‐blind, randomized, placebo‐controlled study of adefovir dipivoxil (ADV) 10 mg once daily.

Management of patients with biliary atresia in France: Results of a decentralized policy 1986‐2002

Marie‐Odile Serinet, Pierre Broué, Emmanuel Jacquemin, Alain Lachaux, Jacques Sarles, Frédéric Gottrand, Frédéric Gauthier, Christophe Chardot – 23 June 2006 – This study analyzed the results of the decentralized management of biliary atresia (BA) in France, where an improved collaboration between centers has been promoted since 1997. Results were compared to those obtained in England and Wales, where BA patients have been centralized in three designated centers since 1999.

Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity

Ton Lisman, Tamara N. Bongers, Jelle Adelmeijer, Harry L.A. Janssen, Moniek P.M. de Maat, Philip G. de Groot, Frank W.G. Leebeek – 23 June 2006 – Cirrhosis of the liver is frequently accompanied by complex alterations in the hemostatic system, resulting in a bleeding tendency. Although many hemostatic changes in liver disease promote bleeding, compensatory mechanisms also are found, including high levels of the platelet adhesive protein von Willebrand Factor (VWF). However, conflicting reports on the functional properties of VWF in cirrhosis have appeared in literature.

Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence

Julia L. Newton, G. John Gibson, Mark Tomlinson, Katharine Wilton, David Jones – 23 June 2006 – A significant proportion of patients with primary biliary cirrhosis (PBC) suffer from severe fatigue. The aim of this study was to characterize patterns of daytime sleep in patients with PBC (using both objective and subjective assessment approaches) and to study the association between sleep abnormality and fatigue severity.

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