Interindividual variability of canalicular ATP‐binding‐cassette (ABC)–transporter expression in human liver

Yvonne Meier, Christiane Pauli‐Magnus, Ulrich M. Zanger, Kathrin Klein, Elke Schaeffeler, Andreas K. Nussler, Natascha Nussler, Michel Eichelbaum, Peter J. Meier, Bruno Stieger – 23 June 2006 – Interindividual variability in hepatic canalicular transporter expression might predispose to the development of hepatic disorders such as acquired forms of intrahepatic cholestasis.

Development of autoimmune hepatitis in patients with typical primary biliary cirrhosis

Raoul Poupon, Olivier Chazouilleres, Christophe Corpechot, Yves Chrétien – 23 June 2006 – Primary biliary cirrhosis (PBC)–autoimmune hepatitis (AIH) overlap syndrome is a clinical entity characterized by the occurence of both conditions at the same time in the same patient. In addition to PBC‐AIH overlap syndrome, transitions from one autoimmune disease to another have been reported, but no systematic series have been published. We report a series of 12 patients with consecutive occurrence of PBC and AIH (i.e., PBC followed by AIH).

Enhancement by pyrazole of lipopolysaccharide‐induced liver injury in mice: Role of cytochrome P450 2E1 and 2A5

Yongke Lu, Arthur I. Cederbaum – 23 June 2006 – The mechanisms by which alcohol causes liver injury are still not certain. Either LPS or CYP2E1 are considered independent risk factors involved in alcoholic liver disease, but mutual relationships or interactions between them are unknown. In the present study, the possible synergistic action of CYP2E1 and LPS in liver injury was investigated by evaluating the effects of pyrazole (inducer of CYP2E1), Chlormethiazole (CMZ), an inhibitor of CYP2E1, and CYP2E1‐knockout mice.

Hereditary lysozyme amyloidosis: Spontaneous hepatic rupture (15 years apart) in mother and daughter. role of emergency liver transplantation

Martin Loss, Wa S. Ng, Rooshdiya Z. Karim, Simone I. Strasser, David J. Koorey, Peter J. Gallagher, Deborah J. Verran, Geoffrey W. McCaughan – 23 June 2006 – Hepatic rupture is a rare condition, and treatment options are very limited. We report a case of hepatic rupture secondary to hereditary lysozyme amyloidosis that was successfully treated by liver transplantation. The mother of this patient had presented in an identical fashion 15 years earlier in the pretransplant era and died very rapidly. Liver Transpl 12:1152–1155, 2006. © 2006 AASLD.

Hematopoietic stem cells mobilized by granulocyte colony‐stimulating factor partly contribute to liver graft regeneration after partial orthotopic liver transplantation

Feng Liu, Xiaoben Pan, Guodong Chen, Dong Jiang, Xu Cong, Ran Fei, Lai Wei – 23 June 2006 – On the basis of the recently recognized potential of hematopoietic stem cells (HSCs) to give rise to hepatocytes, we investigated whether HSCs mobilized by granulocyte colony‐stimulating factor (G‐CSF) or G‐CSF per se could contribute to faster recovery and promote tissue reparation after rats' (cross‐sex) partial orthotopic liver transplantation (PLTx). Sex‐mismatched (female to male) syngeneic rat PLTx was established.

Acquired hepatocerebral degeneration in a patient with HCV cirrhosis: Complete resolution with subsequent recurrence after liver transplantation

Luis Servin‐Abad, Andreas Tzakis, Eugene R. Schiff, Arie Regev – 23 June 2006 – Acquired (non‐Wilsonian) hepatocerebral degeneration (AHD) is a chronic brain disorder caused by liver dysfunction and long‐standing portal‐systemic shunting. It typically presents with dysathria, ataxia, tremor, involuntary movements and altered mental status, and often does not respond to conventional medical therapy for hepatic encephalopathy. There is scarce and conflicting information regarding the clinical course of AHD after liver transplantation (OLT).

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