Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency

A. S. Knisely, Sandra S. Strautnieks, Yvonne Meier, Bruno Stieger, Jane A. Byrne, Bernard C. Portmann, Laura N. Bull, Ludmila Pawlikowska, Banu Bilezikçi, Figen Özçay, Aranka László, László Tiszlavicz, Lynette Moore, Jeremy Raftos, Henrik Arnell, Björn Fischler, Antal Németh, Nikos Papadogiannakis, Joanna Cielecka‐Kuszyk, Irena Jankowska, Joanna Pawłowska, Hector Melín‐Aldana, Karan M. Emerick, Peter F. Whitington, Giorgina Mieli‐Vergani, Richard J. Thompson – 26 July 2006 – Hepatocellular carcinoma (HCC) is rare in young children.

Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race

Xiao‐Song He, Xuhuai Ji, Matthew B. Hale, Ramsey Cheung, Aijaz Ahmed, Yaqian Guo, Garry P. Nolan, Lawrence M. Pfeffer, Teresa L. Wright, Neil Risch, Robert Tibshirani, Harry B. Greenberg – 26 July 2006 – Interferon (IFN)‐α–based therapy for chronic hepatitis C is effective in fewer than 50% of all treated patients, with a substantially lower response rate in black patients. The goal of this study was to investigate the underlying host transcriptional response associated with interferon treatment outcomes.

Probiotics: Application of “healthy” bacteria to liver transplant recipients

Josh Levitsky – 26 July 2006 – Bacterial infections frequently occur early after liver transplantation. We recently reported significant progress with a synbiotic composition, consisting of one lactic acid bacteria (LAB) and one fiber, which reduced the infection rate from 48% (with selective bowel decontamination) to 13%. Now, our aim is to study if a combination of different LAB and fibers would further improve outcome. A prospective randomized double‐blind trial was undertaken in 66 liver transplant recipients. All patients received enteral nutrition immediately post‐operatively.

Statins and hepatic steatosis: Perspectives from the Dallas Heart Study

Jeffrey D. Browning – 26 July 2006 – Non‐alcoholic fatty liver disease (NAFLD) and cardiovascular disease are independently associated. Due to the efficacy of 3‐hydroxy 3‐methylglutaryl‐coenzyme A reductase inhibitors (statins) in the prevention of cardiovascular disease, increasing interest has been shown in establishing the safety of these drugs in NAFLD.

Liver biopsy interpretation for causes of late liver allograft dysfunction

Banff Working Group, A. J. Demetris – 26 July 2006 – Evaluation of needle biopsies and extensive clinicopathological correlation play an important role in the determination of liver allograft dysfunction occurring more than 1 year after transplantation. Interpretation of these biopsies can be quite difficult because of the high incidence of recurrent diseases that show histopathological, clinical, and serological features that overlap with each other and with rejection. Also, more than one insult can contribute to allograft injury.

Pattern recognition receptors: A contemporary view on liver diseases

Gyongyi Szabo, Angela Dolganiuc, Pranoti Mandrekar – 26 July 2006 – Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver.

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