29 March 2007

See Ching Chan, Sheung Tat Fan, Chi Leung Liu, Chung Mau Lo, Banny K. Lam, Evelyn W. Lee – 29 March 2007 – Donor workup for adult‐to‐adult live donor liver transplantation is done to ensure that the donor remains physically and psychologically healthy after saving or improving the life of the recipient. Even though two‐thirds of the liver transplants in our center were from live donors, this life‐saving procedure remains a mere treatment option, given the magnitude of the donor operation with the associated donor risks.

Ashwani Chhibber, Jason Dziak, Jefferey Kolano, J. Russell Norton, Stewart Lustik – 29 March 2007 – A total of 100 patients who underwent elective lobar donor hepatectomy from 2000 to 2002 at the University of Rochester Medical Center were reviewed.

Edie Y. Chan, Anne M. Larson, Terry B. Gernsheimer, Kris V. Kowdley, Robert L. Carithers, Jorge D. Reyes, James D. Perkins – 29 March 2007 – Acute cellular graft‐vs.‐host disease (GVHD) following liver transplantation has an incidence of 1 to 2% and a mortality rate of 85%. Our aim was to identify a patient population at high risk for developing GVHD using a large clinical database to study both recipient and donor factors. We compared our liver transplant patients who developed GVHD to those that did not for recipient and donor factors and combinations of factors.

Evangelos Cholongitas, George V. Papatheodoridis, Paola Zappoli, Athanasios Giannakopoulos, David Patch, Laura Marelli, Vibhakorn Shusang, George Kalambokis, Graham Shirling, Nancy Rolando, A. K. Burroughs – 29 March 2007 – Combined disparity of human leukocyte antigen (HLA)‐DR and ‐DQ between mother and fetus is associated with less severe ulcerative colitis (UC) during pregnancy. We evaluated whether donor‐recipient HLA disparity after liver transplantation (LT) affects UC in patients with primary sclerosing cholangitis (PSC).

Jeremy R. Parfitt, Paul Marotta, Mohammed AlGhamdi, William Wall, Anand Khakhar, Neville G. Suskin, Douglas Quan, Vivian McAllister, Cam Ghent, Mark Levstik, Carolyn McLean, Subrata Chakrabarti, Bertha Garcia, David K. Driman – 29 March 2007 – Milan and University of California at San Francisco (UCSF) criteria are used to select patients with hepatocellular carcinoma (HCC) for liver transplantation (LT). Recurrent HCC is a significant cause of death. There is no widely accepted pathological assessment strategy to predict recurrent HCC after transplantation.

Zhen Fan Yang, Patricia Ngai, Chi Keung Lau, David W. Ho, Ka Ho Tam, Chi Tat Lam, Ronnie T. Poon, Sheung Tat Fan – 29 March 2007 – This study aims to investigate the potential role of endogenous interleukin (IL)‐10 in long‐term liver allograft survival induced by delayed immunosuppression (FK506 days 2‐7). Liver transplantation was performed by using Dark Agouti and Lewis rats as donors and recipients, respectively. The delayed immunosuppression protocol induced indefinite allograft survival.

Zhen Fan Yang, David Wing Yuen Ho, Patricia Ngai, Chi Keung Lau, Yi Zhao, Ronnie Tung Ping Poon, Sheung Tat Fan – 29 March 2007 – The present study aims to investigate the potential therapeutic role of interleukin‐10 (IL‐10) in small‐for‐size liver transplantation. A syngenic rat orthotopic liver transplantation model was performed using either whole or 40% liver volume of Lewis rats as grafts according to the experimental design. IL‐10 was given to the 40% grafts right after reperfusion, and also at 24 and 48 hours after transplantation.

Kristin L. Mekeel, Max R. Langham, Regino Gonzalez‐Peralta, Shiro Fujita, Alan W. Hemming – 29 March 2007 – Severe liver disease is an unusual but potentially fatal complication of sickle‐cell disease (SCD). Liver transplantation has been complicated by ongoing SCD and thrombosis. We reviewed 214 pediatric transplants done at our institution from 1990 to 2005. Three patients were transplanted for complications of SCD, including intrahepatic cholestasis and viral hepatitis. Overall patient and graft survival was 66%. One patient died after 6 years from a subdural hematoma.

Lawrence S. Friedman – 29 March 2007