James D. Perkins – 24 August 2006 – The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5‐HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5‐HT2A and 2B receptors inhibited liver regeneration.

Naoki Shimojima, Rie Shibata, Ken Hoshino, Shigeyuki Kawachi, Minoru Tanabe, Go Wakabayashi, Motohide Shimazu, Michiie Sakamoto, Yasuhide Morikawa, Masaki Kitajima – 24 August 2006 – Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers.

Yasuhiko Sugawara, Masatoshi Makuuchi – 24 August 2006

24 August 2006

Antonio J. Sanchez, Jaime Aranda‐Michel – 24 August 2006 – Patients with end‐stage liver disease (ESLD) frequently have diverse abnormalities of carbohydrate, lipid, and protein metabolism that cause progressive deterioration of their clinical condition and lead to malnutrition. Malnutrition is almost universally present in patients with ESLD undergoing liver transplantation and has been associated with increased morbidity and mortality.

Mitsuhisa Takatsuki, Susumu Eguchi, Hirotaka Tokai, Masaaki Hidaka, Akihiko Soyama, Yoshitsugu Tajima, Takashi Kanematsu – 24 August 2006

See Ching Chan, Sheung Tat Fan – 24 August 2006

Guy Maddern – 24 August 2006

Ramazan Idilman, Sadik Ersoz, Sahin Coban, Ozlem Kumbasar, Hakan Bozkaya – 24 August 2006 – Standard antituberculous therapy including isoniazid, rifampin, ethambutol, and pyrazinamide is widely used for the treatment of active tuberculosis. Its most important side effect is hepatotoxicity, ranging from asymptomatic transaminitis to fulminant hepatic failure. A 19‐year‐old woman was admitted to our unit due to jaundice and unconsciousness. According to her past medical history, she was diagnosed as having extrapulmonary tuberculosis and had been prescribed standard antituberculous therapy.

Ludivine Falize, Anne Guillygomarc'h, Michele Perrin, Fabrice Lainé, Dominique Guyader, Pierre Brissot, Bruno Turlin, Yves Deugnier – 26 July 2006 – The current study was undertaken to assess whether fibrosis could regress under venesection therapy in patients with C282Y homozygous genetic hemochromatosis. The 36 patients studied were recruited from a subfile of our database consisting of 125 C282Y homozygotes with either severe fibrosis or cirrhosis (F3 or F4 fibrosis stage, respectively, according to the METAVIR grading system).