Vasor: Accurate prediction of variant effects for amino acid substitutions in multidrug resistance protein 3
Annika Behrendt, Pegah Golchin, Filip König, Daniel Mulnaes, Amelie Stalke, Carola Dröge, Verena Keitel, Holger Gohlke – 15 September 2022 – The phosphatidylcholine floppase multidrug resistance protein 3 (MDR3) is an essential hepatobiliary transport protein. MDR3 dysfunction is associated with various liver diseases, ranging from severe progressive familial intrahepatic cholestasis to transient forms of intrahepatic cholestasis of pregnancy and familial gallstone disease.