Molecular networks of hepatoblastoma predisposition and oncogenesis in Beckwith‐Wiedemann syndrome
Natali S. Sobel Naveh, Emily M. Traxler, Kelly A. Duffy, Jennifer M. Kalish – 3 May 2022 – Beckwith‐Wiedemann Syndrome (BWS) is the most common human overgrowth disorder caused by structural and epigenetic changes to chromosome 11p15. Patients with BWS are predisposed to developing hepatoblastoma (HB). To better understand the mechanism of HB oncogenesis in this cancer predisposition background, we performed the first multi‐dimensional study of HB samples collected from patients diagnosed with BWS.