Setting up criteria for drug‐induced autoimmune‐like hepatitis through a systematic analysis of published reports

Einar S. Björnsson, Inmaculada Medina‐Caliz, Raul J. Andrade, M. Isabel Lucena – 20 May 2022 – Nitrofurantoin, minocycline, methyldopa and infliximab, have been found to induce autoimmune‐like hepatitis (DI‐AILH). Evidence for other drugs and herbal and dietary supplements (HDS) is unclear. The aims of the study were to establish criteria to define and review the published evidence of suspected DI‐AILH.

Organoids and regenerative hepatology

Nidhi Jalan‐Sakrikar, Teresa Brevini, Robert C. Huebert, Fotios Sampaziotis – 20 May 2022 – The burden of liver diseases is increasing worldwide, with liver transplantation remaining the only treatment option for end‐stage liver disease. Regenerative medicine holds great potential as a therapeutic alternative, aiming to repair or replace damaged liver tissue with healthy functional cells. The properties of the cells used are critical for the efficacy of this approach.

Mas‐related G protein‐coupled receptor type D antagonism improves portal hypertension in cirrhotic rats

Lakmie S. Gunarathne, Indu G. Rajapaksha, Stephen Casey, Tawar Qaradakhi, Anthony Zulli, Harinda Rajapaksha, Jonel Trebicka, Peter W. Angus, Chandana B. Herath – 19 May 2022 – Splanchnic vasodilatation contributes to the development and aggravation of portal hypertension (PHT). We previously demonstrated that in cirrhosis, angiotensin‐ mediates splanchnic vasodilatation through the Mas receptor (MasR).

Prophylactic effect of tenofovir on viral reactivation in immunocompromised pregnant women living with hepatitis B virus

Le Zhang, Shaoying Yang, Yongfu Yu, Suli Wang, Yuetian Yu, Yi Jin, Aimin Zhao, Yimin Mao, Liangjing Lu – 19 May 2022 – The appropriate prophylaxis for hepatitis B virus reactivation (HBVr) during gestation for immunocompromised pregnant women has yet to be determined. The prophylactic efficacy and safety of tenofovir disoproxil fumarate (TDF) in hepatitis B surface antigen (HBsAg)–positive patients and the HBVr risk in hepatitis B core antibody (HBcAb)–positive patients during gestation were investigated.

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