Prophylactic effect of tenofovir on viral reactivation in immunocompromised pregnant women living with hepatitis B virus

Le Zhang, Shaoying Yang, Yongfu Yu, Suli Wang, Yuetian Yu, Yi Jin, Aimin Zhao, Yimin Mao, Liangjing Lu – 19 May 2022 – The appropriate prophylaxis for hepatitis B virus reactivation (HBVr) during gestation for immunocompromised pregnant women has yet to be determined. The prophylactic efficacy and safety of tenofovir disoproxil fumarate (TDF) in hepatitis B surface antigen (HBsAg)–positive patients and the HBVr risk in hepatitis B core antibody (HBcAb)–positive patients during gestation were investigated.

Journals

Read the latest article abstracts, practice guidelines, and more from HEPATOLOGY, Liver Transplantation, Clinical Liver Disease and Hepatology Communications.

Strategic Plan

With continuous progress and measurement to ensure we are meeting our goals, AASLD is forging a new path to support the hepatology community in advancing the science of liver disease.

Beyond circadian rhythms: emerging roles of ultradian rhythms in control of liver functions

Gad Asher, Bokai Zhu – 18 May 2022 – The mammalian liver must cope with various metabolic and physiological changes that normally recur every day and primarily stem from daily cycles of rest‐activity and fasting‐feeding. Although a large body of evidence supports the reciprocal regulation of circadian rhythms and liver function, the research on the hepatic ultradian rhythms have largely been lagging behind.

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio – 18 May 2022 – Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to the development of diabetes, steatosis, and insulin resistance.

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