AASLD 2005 distinguished achievement award to Dr. Jenny Heathcote
Samuel S. Lee – 29 November 2005
Reply:
Gary A. Abrams, Ronald H. Clements, Audrey J. Lazenby, Sachin S. Kunde – 29 November 2005
HCV: Alive and kicking in living donor liver grafts?
Xavier Forns – 29 November 2005
Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors
Thomas D. Schiano, Julio A. Gutierrez, Jose L. Walewski, M. Isabel Fiel, Bonnie Cheng, Henry Bodenheimer, Swan N. Thung, Raymond T. Chung, Myron E. Schwartz, Carol Bodian, Andrea D. Branch – 29 November 2005 – This study tested the hypothesis that hepatitis C virus (HCV) RNA and core antigen levels rise more rapidly after liver transplantation (LT) in recipients of grafts from living donors (LD) versus deceased donors (DD). Eleven consecutive LD and 15 DD recipients were followed prospectively. Before LT, median HCV RNA levels were similar: 5.42 (LDLT) and 5.07 (DDLT) log10 IU/mL (P = NS).
Alcohol increases tumor necrosis factor α and decreases nuclear factor‐κb to activate hepatic apoptosis in genetically obese mice
Marie‐Anne Robin, Christine Demeilliers, Angéla Sutton, Valérie Paradis, Caroline Maisonneuve, Sylvie Dubois, Odile Poirel, Philippe Lettéron, Dominique Pessayre, Bernard Fromenty – 29 November 2005 – Both obesity and alcohol can cause oxidative stress, cytokine induction, and steatohepatitis. To determine the consequences of their combination, we compared the hepatic effects of moderate ethanol binges in lean and obese ob/ob mice. Mice received water or ethanol (2.5 g/kg) by gastric intubation daily for 4 days, and were killed 2 hours after the last administration.
AASLD 2005 distinguished service award to Dr. Leonard B. Seeff
Jay H. Hoofnagle – 29 November 2005
Microcirculation of the aging liver: Is getting old like having cirrhosis?
Pierre‐Michel Huet, Jean‐Pierre Villeneuve – 29 November 2005
A novel system for efficient gene transfer into primary human hepatocytes via cell‐permeable hepatitis B virus–like particle
Boerries Brandenburg, Lars Stockl, Cindy Gutzeit, Martin Roos, Joachim Lupberger, Ruth Schwartlander, Hans Gelderblom, Igor M. Sauer, Peter Hans Hofschneider, Eberhard Hildt – 29 November 2005 – Protein transduction domains (PTDs) have been used to deliver a variety of biologically active cargo across cellular membranes. However the potential of PTDs to mediate transport of nanoparticular structures into the cytoplasm bypassing the endosomal compartment remains unclear.
Intrahepatic cholestasis of pregnancy: A randomized controlled trial comparing dexamethasone and ursodeoxycholic acid
Anna Glantz, Hanns‐Ulrich Marschall, Frank Lammert, Lars‐Åke Mattsson – 29 November 2005 – Intrahepatic cholestasis of pregnancy (ICP) is characterized by troublesome maternal pruritus, elevated serum bile acids (≥10 μmol/L) and increased fetal risk. Recently we determined a cutoff level of serum bile acids, ≥40 μmol/L, to be associated with impaired fetal outcome. We have now studied the effects of ursodeoxycholic acid (UDCA) and dexamethasone on pruritus, biochemical markers of cholestasis, and fetal complication rates in a double‐blind, placebo‐controlled trial.
Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
Sara Aleffi, Ilaria Petrai, Cristiana Bertolani, Maurizio Parola, Sebastiano Colombatto, Erica Novo, Francesco Vizzutti, Frank A. Anania, Stefano Milani, Krista Rombouts, Giacomo Laffi, Massimo Pinzani, Fabio Marra – 29 November 2005 – Leptin upregulates collagen expression in hepatic stellate cells (HSCs), but the possible modulation of other actions has not been elucidated. The aim of this study was to investigate the expression and function of leptin receptors (ObR) in human HSCs and the biological actions regulated by leptin.