Mélanie Verreault, Kathy Senekeo‐Effenberger, Jocelyn Trottier, Jessica A. Bonzo, Julie Bélanger, Jenny Kaeding, Bart Staels, Patrick Caron, Robert H. Tukey, Olivier Barbier – 26 July 2006 – Glucuronidation, an important bile acid detoxification pathway, is catalyzed by enzymes belonging to the UDP‐glucuronosyltransferase (UGT) family. Among UGT enzymes, UGT1A3 is considered the major human enzyme for the hepatic C24‐glucuronidation of the primary chenodeoxycholic (CDCA) and secondary lithocholic (LCA) bile acids.

26 July 2006

C. Corpechot, A. El Naggar, R. Poupon – 26 July 2006

Chihiro Morishima, Timothy R. Morgan, James E. Everhart, Elizabeth C. Wright, Mitchell L. Shiffman, Gregory T. Everson, Karen L. Lindsay, Anna S. F. Lok, Herbert L. Bonkovsky, Adrian M. Di Bisceglie, William M. Lee, Jules L. Dienstag, Marc G. Ghany, David R. Gretch, HALT‐C Trial Group – 26 July 2006 – For making treatment decisions related to chronic hepatitis C, the utility of HCV RNA tests with increased sensitivity has not been defined. Prior interferon nonresponders with advanced fibrosis (n = 1,145) were retreated with peginterferon alpha‐2a and ribavirin.

Armando Tripodi, Massimo Primignani, Veena Chantarangkul, Marigrazia Clerici, Alessandra Dell'Era, Federica Fabris, Francesco Salerno, Pier Mannuccio Mannucci – 26 July 2006 – Coagulation factor defects, thrombocytopenia, and thrombocytopathy are associated with cirrhosis. However, bleeding in patients who have cirrhosis does not entirely correlate with abnormal coagulation tests.

Gyongyi Szabo, Angela Dolganiuc, Pranoti Mandrekar – 26 July 2006 – Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver.

Banff Working Group, A. J. Demetris – 26 July 2006 – Evaluation of needle biopsies and extensive clinicopathological correlation play an important role in the determination of liver allograft dysfunction occurring more than 1 year after transplantation. Interpretation of these biopsies can be quite difficult because of the high incidence of recurrent diseases that show histopathological, clinical, and serological features that overlap with each other and with rejection. Also, more than one insult can contribute to allograft injury.

Stephen N. Wong, Anna S.F. Lok – 26 July 2006

Cecilia M.P. Rodrigues, Clifford J. Steer – 26 July 2006

Jeffrey D. Browning – 26 July 2006 – Non‐alcoholic fatty liver disease (NAFLD) and cardiovascular disease are independently associated. Due to the efficacy of 3‐hydroxy 3‐methylglutaryl‐coenzyme A reductase inhibitors (statins) in the prevention of cardiovascular disease, increasing interest has been shown in establishing the safety of these drugs in NAFLD.