Impact of cytomegalovirus prophylaxis on rejection following orthotopic liver transplantation

Michelle Slifkin, Robin Ruthazer, Richard Freeman, Judy Bloom, Susan Fitzmaurice, Ralph Fairchild, Michael Angelis, Jeffrey Cooper, Laurie Barefoot, Richard Rohrer, David R. Snydman – 28 November 2005 – With improved cytomegalovirus (CMV) prophylaxis, CMV disease after liver transplantation has decreased dramatically, and patient and graft survival have improved. We examined the impact of CMV prophylaxis on biopsy proven rejection after orthotopic liver transplantation by analyzing data on 192 liver recipients over 5 years (1994‐1999).

The effect of HLA mismatches, shared cross‐reactive antigen groups, and shared HLA‐DR antigens on the outcome after pediatric liver transplantation

Egbert Sieders, Bouke G. Hepkema, Paul M.J.G. Peeters, Elisabeth M. TenVergert, Koert P. de Jong, Robert J. Porte, Charles M.A. Bijleveld, Aad P. van den Berg, Simon P.M. Lems, Annette S.H. Gouw, Maarten J.H. Slooff – 28 November 2005 – The aim of this study was to analyze the effect of human leukocyte antigen (HLA) class I and HLA‐DR mismatching, sharing cross‐reactive antigen groups (CREGs), and sharing HLA‐DR antigens on the outcome after pediatric liver transplantation. Outcome parameters were graft survival, acute rejection, and portal fibrosis.

High preoperative recipient plasma 7β‐hydroxycholesterol is associated with initial poor graft function after liver transplantation

Stefano Ginanni Corradini, Fausta Micheletta, Silvia Natoli, Massimo Iappelli, Emanuele Di Angelantonio, Rosanna De Marco, Walter Elisei, Maria Siciliano, Massimo Rossi, Pasquale Berloco, Adolfo Francesco Attili, Ulf Diczfalusy, Luigi Iuliano – 28 October 2005 – Oxidative stress is implicated in the pathogenesis of hepatic ischemia‐reperfusion injury, a major determinant of initial poor graft function (IPGF) after orthotopic liver transplantation (OLT).

Variceal hemorrhage and cystic fibrosis: Outcomes and implications for liver transplantation

Ian Gooding, Vicky Dondos, Khin Ma Gyi, Margaret Hodson, David Westaby – 28 October 2005 – Autopsy and imaging studies show that liver involvement is common in cystic fibrosis. However, complications of chronic liver disease including portal hypertension and variceal bleeding are infrequently encountered, and the degree to which variceal hemorrhage affects prognosis in cystic fibrosis is unclear. This uncertainty has lead to debate as to whether liver transplantation is indicated in these patients.

A high‐fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF‐κB inhibitor, IκBα

Robert A. DeAngelis, Maciej M. Markiewski, Rebecca Taub, John D. Lambris – 25 October 2005 – Despite the growing incidence of obesity, knowledge of how this condition, as well as associated steatosis, affects liver regeneration remains scarce. Many previous studies have used models of steatohepatitis or obesity induced by genetic alterations. In contrast, our studies on liver regeneration have focused on the effects of obesity resulting solely from high amounts of fat in the diet.

High prevalence of spontaneous portal‐systemic shunts in persistent hepatic encephalopathy: A case‐control study

Oliviero Riggio, Cesare Efrati, Carlo Catalano, Federica Pediconi, Oriano Mecarelli, Neri Accornero, Francesca Nicolao, Stefania Angeloni, Andrea Masini, Lorenzo Ridola, Adolfo F. Attili, Manuela Merli – 25 October 2005 – Large spontaneous portal‐systemic shunts have been occasionally described in patients with cirrhosis. This study was undertaken to assess the prevalence of portal‐systemic shunts in patients with cirrhosis with recurrent or persistent hepatic encephalopathy (HE) as compared with patients with cirrhosis without HE.

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