MinDe Zeng, YiMin Mao, GuangBi Yao, Hao Wang, JinLin Hou, YaoZong Wang, Beulah N. Ji, Chai‐Ni P. Chang, Keith F. Barker – 23 June 2006 – Four hundred and eighty Chinese subjects with hepatitis B e antigen (HBeAg)–positive chronic hepatitis B (CHB) were enrolled in a multicenter, double‐blind, randomized, placebo‐controlled study of adefovir dipivoxil (ADV) 10 mg once daily.
Gemma R. Grant, Susan W. Robinson, Richard E. Edwards, Bruce Clothier, Reginald Davies, David J. Judah, Karl W. Broman, Andrew G. Smith – 23 June 2006 – Polymorphisms of genes linked to iron metabolism may account for individual variability in hemochromatosis and iron status connected with liver and cardiovascular diseases, cancers, toxicity, and infection. Mouse strains exhibit marked differences in levels of non‐heme iron, with C57BL/6J and SWR showing low and high levels, respectively.
Andres T. Blei – 23 June 2006
Anne Bessard, Alexandre Coutant, Claude Rescan, Frédéric Ezan, Christophe Frémin, Brice Courselaud, Gennady Ilyin, Georges Baffet – 23 June 2006 – We show that MLCK (myosin light chain kinase) plays a key role in cell cycle progression of hepatocytes: either chemical inhibitor ML7 or RNA interference led to blockade of cyclin D1 expression and DNA replication, providing evidence that MLCK regulated S phase entry. Conversely, inhibition of RhoK by specific inhibitor Y27632 or RhoK dominant‐negative vector did not influence progression in late G1 and S phase entry.
Ulrich Beuers, Guido Gerken, Thomas Pusl – 23 June 2006
Nicolas Jabbour, Singh Gagandeep – 23 June 2006
Andrea Frilling, Massimo Malago, Frank Weber, Andreas Paul, Silvio Nadalin, Georgios C. Sotiropoulos, Vito Cicinnati, Susanne Beckebaum, Andreas Bockisch, Jan Mueller‐Brand, Michael Hofmann, Kurt W. Schmid, Guido Gerken, Christoph E. Broelsch – 23 June 2006 – In contrast to other secondary liver malignancy, orthotopic liver transplantation (OLT) is considered as a treatment modality for nonresectable endocrine liver metastases in selected patients.
Douglas Thorburn, Kirsty Roy, Karen Wilson, David Stell, Sheila Cameron, William Wall, Peter R. Mills, David Goldberg – 23 June 2006 – The risk of hepatitis C virus (HCV) transmission to surgeons is related to the HCV prevalence in the surgical patient population. As HCV‐related cirrhosis is the commonest indication for liver transplantation in Europe and North America, liver transplant surgeons are at particular risk. The prevalence of HCV infection in liver transplant surgeons is unknown.
Lucio F Pacheco‐Moreira, Marcelo Enne, Elizabeth Balbi – 23 June 2006
Vasilica Matei, Aina Rodríguez‐Vilarrupla, Ramon Deulofeu, Dolors Colomer, Mercedes Fernández, Jaime Bosch, Juan‐Carlos Garcia‐Pagán – 23 June 2006 – In cirrhosis, intrahepatic endothelial dysfunction is one of the mechanisms involved in the increased resistance to portal blood flow and therefore in the development of portal hypertension. Endothelial nitric oxide synthase (eNOS) uncoupling due to deficiency of tetrahydrobiopterin (BH4) results in decreased production of NO and plays a major role in endothelial dysfunction in other conditions.