Comparison of cyclosporine microemulsion and tacrolimus in 39 recipients of living donor liver transplantation

Koichi Tanaka, John Lake, Federico Villamil, Gary Levy, Paul Marotta, Sergio Mies, Bernard de Hemptinne, Christian Moench – 19 October 2005 – New immunosuppressive agents and regimens should be evaluated specifically in living donor liver transplant patients due to potential clinical and pharmacokinetic differences between deceased donor and living donor transplant recipients.

Improved machine perfusion preservation of the non‐heart‐beating donor rat liver using polysol: A new machine perfusion preservation solution

Maud Bessems, Benedict M. Doorschodt, Jan van Marle, Heleen Vreeling, Alfred J. Meijer, Thomas M. van Gulik – 19 October 2005 – Waiting lists for transplantation have stimulated interest in the use of non‐heart‐beating donor (NHBD) organs. Recent studies on organ preservation have shown advantages of machine perfusion (MP) over cold storage (CS). To supply the liver with specific nutrients during MP, the preservation solution Polysol was developed. The aim of our study was to compare CS in University of Wisconsin solution (UW) with MP using UW‐gluconate (UW‐G) or Polysol in an NHBD model.

Mesogonadal shunts for extrahepatic portal vein thrombosis and variceal hemorrhage

Heung Bae Kim, James J. Pomposelli, Craig W. Lillehei, Roger L. Jenkins, Maureen M. Jonas, Laura E. Krawczuk, Steven J. Fishman – 19 October 2005 – Extrahepatic portal vein thrombosis (EHPVT) may occur in children or adults and usually comes to clinical attention due to complications of portal hypertension such as variceal hemorrhage. A variety of standard surgical techniques exist to manage these patients, but when these fail surgical options are limited. We describe two novel portosystemic shunts that utilize the gonadal vein as an autologous conduit.

Immunosuppression for liver transplantation in HCV‐infected patients: Mechanism‐based principles

Bijan Eghtesad, John J. Fung, Anthony J. Demetris, Noriko Murase, Roberta Ness, Debra C. Bass, Edward A. Gray, Obaid Shakil, Bridget Flynn, Amadeo Marcos, Thomas E. Starzl – 19 October 2005 – We retrospectively analyzed 42 hepatitis C virus (HCV)‐infected patients who underwent cadaveric liver transplantation under two strategies of immunosuppression: (1) daily tacrolimus (TAC) throughout and an initial cycle of high‐dose prednisone (PRED) with subsequent gradual steroid weaning, or (2) intraoperative antithymocyte globulin (ATG) and daily TAC that was later space weaned.

Cerebral hemodynamic and metabolic profiles in fulminant hepatic failure: Relationship to outcome

Shushma Aggarwal, Walter Obrist, Howard Yonas, David Kramer, Yoogoo Kang, Victor Scott, Raymond Planinsic – 19 October 2005 – The purpose of this retrospective study was to examine the potential role of cerebral hemodynamic and metabolic factors in the outcome of patients with fulminant hepatic failure (FHF). Based on the literature, a hypothetical model was proposed in which physiologic changes progress sequentially in five phases, as defined by intracranial pressure (ICP) and cerebral blood flow (CBF) measurements.

Current role of liver transplantation for the treatment of urea cycle disorders: A review of the worldwide English literature and 13 cases at Kyoto University

Daisuke Morioka, Mureo Kasahara, Yasutsugu Takada, Yasumasa Shirouzu, Kaoru Taira, Seisuke Sakamoto, Kenji Uryuhara, Hiroto Egawa, Hiroshi Shimada, Koichi Tanaka – 19 October 2005 – To address the current role of liver transplantation (LT) for urea cycle disorders (UCDs), we reviewed the worldwide English literature on the outcomes of LT for UCD as well as 13 of our own cases of living donor liver transplantation (LDLT) for UCD. The total number of cases was 51, including our 13 cases. The overall cumulative patient survival rate is presumed to be more than 90% at 5 years.

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