Development of autoimmune hepatitis in patients with typical primary biliary cirrhosis

Raoul Poupon, Olivier Chazouilleres, Christophe Corpechot, Yves Chrétien – 23 June 2006 – Primary biliary cirrhosis (PBC)–autoimmune hepatitis (AIH) overlap syndrome is a clinical entity characterized by the occurence of both conditions at the same time in the same patient. In addition to PBC‐AIH overlap syndrome, transitions from one autoimmune disease to another have been reported, but no systematic series have been published. We report a series of 12 patients with consecutive occurrence of PBC and AIH (i.e., PBC followed by AIH).

Interindividual variability of canalicular ATP‐binding‐cassette (ABC)–transporter expression in human liver

Yvonne Meier, Christiane Pauli‐Magnus, Ulrich M. Zanger, Kathrin Klein, Elke Schaeffeler, Andreas K. Nussler, Natascha Nussler, Michel Eichelbaum, Peter J. Meier, Bruno Stieger – 23 June 2006 – Interindividual variability in hepatic canalicular transporter expression might predispose to the development of hepatic disorders such as acquired forms of intrahepatic cholestasis.

Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell–mediated hepatitis

Michael Kremer, Ian Neil Hines, Richard Jameson Milton, Michael Daryl Wheeler – 23 June 2006 – Steatohepatitis enhances the severity of liver injury caused by acute inflammation. The purpose of this study was to test the hypothesis that fatty liver due to chronic choline‐deficient diet exacerbates concanavalin A (ConA)‐induced liver hepatitis, which is predominantly facilitated by T cells. Male C57BL/6 mice were fed either control choline‐sufficient diet (CSD) or choline‐deficient diet (CDD) for 6 weeks before ConA administration.

Adherence to medication after liver transplantation in Scotland: A pilot study

Ronan E. O'Carroll, Lesley M. McGregor, Vivien Swanson, George Masterton, Peter C. Hayes – 13 June 2006 – This study assessed adherence to medication after liver transplantation and consisted of 2 components: a retrospective audit involving the examination of the Scottish national database, and a preliminary study assessing psychological factors implicated in poor adherence.

Long‐term outcomes of 600 living donor liver transplants for pediatric patients at a single center

Mikiko Ueda, Fumitaka Oike, Yasuhiro Ogura, Kenji Uryuhara, Yasuhiro Fujimoto, Mureo Kasahara, Kohei Ogawa, Koichi Kozaki, Hironori Haga, Koichi Tanaka – 13 June 2006 – This report concerns the long‐term outcome of living donor liver transplantation (LDLT) for pediatric patients at a single center. Between June 1990 and December 2003, a total of 600 LDLTs, including 568 primary transplantations and 32 retransplantations, were performed for pediatric patients, who were immunosuppressed with FK506 and low‐dose corticosteroids.

Outcome and quality of life in patients with polycystic liver disease after liver or combined liver‐kidney transplantation

Gabriele I. Kirchner, Kinan Rifai, Tobias Cantz, Bjoern Nashan, Christoph Terkamp, Thomas Becker, Christian Strassburg, Hannelore Barg‐Hock, Siegfried Wagner, Rainer Lück, Juergen Klempnauer, Michael P. Manns – 1 June 2006 – In advanced stages of polycystic liver disease, often associated with polycystic kidney disease, a curative therapy is liver or combined liver‐kidney transplantation. However, little is known about long‐term outcome and quality of life.

Molecular adsorbent recirculating system in patients with early allograft dysfunction after liver transplantation: A pilot study

Hubert Hetz, Peter Faybik, Gabriela Berlakovich, Amir Baker, Andreas Bacher, Christopher Burghuber, Sigrid E. Sandner, Heinz Steltzer, Claus Georg Krenn – 1 June 2006 – Early allograft dysfunction (EAD) after orthotopic liver transplantation (OLT) causes marked morbidity and mortality. We conducted a prospective pilot study to assess the safety and efficacy of molecular adsorbent recirculating system (MARS) in treatment of EAD after OLT.

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