Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation
Xiu‐Da Shen, Feng Gao, Bibo Ke, Yuan Zhai, Charles R. Lassman, Sei‐Ichiro Tsuchihashi, Douglas G. Farmer, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 23 September 2005 – The current models of liver ischemia/reperfusion injury (IRI) in mice are largely limited to a warm ischemic component. To investigate the mechanism of hepatic “cold” IRI, we developed and validated a new mouse model of prolonged cold preservation followed by syngeneic orthotopic liver transplantation (OLT).