Evaluation for liver transplantation: Adherence to AASLD referral guidelines in a large veterans affairs center

Venodhar R. Julapalli, Jennifer R. Kramer, Hashem B. El‐Serag – 23 September 2005 – Access of patients to liver transplantation involves three levels: referral for evaluation for transplantation, placement on a waiting list for transplantation, and receipt of a liver transplant. No study has formally evaluated access to liver transplantation at the referral level. Therefore, we sought to estimate the magnitude and determinants of consideration of liver transplantation in patients at a single, large Veterans Affairs medical center.

Gc‐globulin and prognosis in acute liver failure

Frank V. Schiødt, Lorenzo Rossaro, Richard T. Stravitz, A. Obaid Shakil, Raymond T. Chung, William M. Lee, Acute Liver Failure Study Group – 23 September 2005 – Serum concentrations of the actin scavenger Gc‐globulin are reduced in acute liver failure (ALF). Prospectively, we tested Gc‐globulin's value to predict outcome following ALF using sera from 182 patients with ALF from the U.S. ALF Study Group. Admission serum levels of Gc‐globulin (normal range: 350‐500 mg/L) were studied by an immunonephelometric method.

Recurrent primary biliary cirrhosis: Peritransplant factors and ursodeoxycholic acid treatment post‐liver transplant

Jennifer E. Guy, Peiqing Qian, Jeffrey A. Lowell, Marion G. Peters – 23 September 2005 – Primary biliary cirrhosis (PBC) recurs after orthotopic liver transplantation (OLT) in up to one‐third of patients. These patients are typically asymptomatic, can be identified by abnormal liver biochemistries, and have evidence of histologic recurrence on liver biopsy. The effect of treatment on recurrence has not been determined. This pilot study evaluates the factors associated with recurrent PBC and describes our experience using ursodeoxycholic acid treatment in this patient population.

Genome‐wide response of the human Hep3B hepatoma cell to proinflammatory cytokines, from transcription to translation

Cédric Coulouarn, Grégory Lefebvre, Romain Daveau, Franck Letellier, Martine Hiron, Laurent Drouot, Maryvonne Daveau, Jean‐Philippe Salier – 20 September 2005 – Given the unknown timing of the onset of an acute systemic inflammation in humans, the fine tuning of cascades and pathways involved in the associated hepatocyte response cannot be appraised in vivo. Therefore, the authors used a genome‐wide and kinetic analysis in the human Hep3B hepatoma cell line challenged with a conditioned medium from bacterial lipopolysaccharide‐stimulated macrophages.

Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis

Tin Ky Mao, Zhe‐Xiong Lian, Carlo Selmi, Yasunori Ichiki, Paul Ashwood, Aftab A. Ansari, Ross L. Coppel, Shinji Shimoda, Hiromi Ishibashi, M. Eric Gershwin – 20 September 2005 – The role of the adaptive immune response, with regard to the development of autoantibodies, has been extensively studied in primary biliary cirrhosis (PBC). However, the importance of innate immunity has been noted only recently.

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