Laura M. Kulik, Mary F. Mulcahy, Russell D. Hunter, Albert A. Nemcek, Michael M. Abecassis, Riad Salem – 25 August 2005 – Prior to therapy, model for end stage liver disease (MELD) scoring, diagnostic imaging and tumor staging were performed in a patient with T3 HCC. The patient received an orthotopic liver transplant (OLT) 42 days after treatment. The explant specimen showed complete necrosis of the target tumor. Follow‐up of this patient has demonstrated no evidence of recurrence. There was no life threatening or fatal adverse experiences related to treatment.

Valentina Medici, Vincenzo G. Mirante, Luigi R. Fassati, Maurizio Pompili, Domenico Forti, Massimo Del Gaudio, Carlo P. Trevisan, Umberto Cillo, Giacomo C. Sturniolo, Stefano Fagiuoli – 25 August 2005 – A retrospective data analysis on liver transplantation for Wilson's disease (WD) was performed among Italian Liver Transplant Centers. Thirty‐seven cases were identified. The main indication for liver transplantation was chronic advanced liver disease in 78% of patients. Mixed hepatic and neuropsychiatric symptoms were recorded in 32.3%.

A. Obaid Shakil – 25 August 2005

Michael J. Krowka – 25 August 2005

Loukas Argyriou, Robert Pfitzmann, Lars‐Erik Wehner, Stefan Twelkemeyer, Peter Neuhaus, Karim Nayernia, Wolfgang Engel – 25 August 2005 – Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominantly inherited disorder characterized by cutaneous and mucosal telangiectasias, epistaxis and arteriovenous malformations in lung, liver, central nervous system, and gastrointestinal tract. Mutations in the genes for endoglin (ENG) and for activin A receptor type II‐like kinase 1 (ALK‐1) have been identified to be associated with HHT.

Timothy M. Pawlik, Keith A. Delman, Jean‐Nicolas Vauthey, David M. Nagorney, Irene Oi‐Lin Ng, Iwao Ikai, Yoshio Yamaoka, Jacques Belghiti, Gregory Y. Lauwers, Ronnie T. Poon, Eddie K. Abdalla – 25 August 2005 – Vascular invasion and high histologic grade predict poor outcome after surgical resection or liver transplantation for hepatocellular carcinoma (HCC). Despite the known association between tumor size and vascular invasion, a proportion of patients with large tumors can be treated surgically with excellent outcomes.

Maurizio Pompili, Vincenzo Giorgio Mirante, Gianfranco Rondinara, Luigi Rainero Fassati, Fabio Piscaglia, Salvatore Agnes, Marcello Covino, Matteo Ravaioli, Stefano Fagiuoli, Giovanni Gasbarrini, Gian Ludovico Rapaccini – 25 August 2005 – Aims of this retrospective study were to analyze the efficacy and safety of percutaneous ethanol injection (PEI) and radiofrequency ablation (RFA) in cirrhotic patients with hepatocellular carcinoma (HCC) submitted to orthotopic liver transplantation (OLT).

Steven M. Kawut, Darren B. Taichman, Vivek N. Ahya, Sandra Kaplan, Christine L. Archer‐Chicko, Stephen E. Kimmel, Harold I. Palevsky – 25 August 2005 – It is not known whether patients with pulmonary arterial hypertension associated with portal hypertension (portopulmonary hypertension (PPHTN) have different disease characteristics from those of patients with other forms of pulmonary arterial hypertension.

Georgios K. Glantzounis, Henryk J. Salacinski, Wenxuan Yang, Brian R. Davidson, Alexander M. Seifalian – 25 August 2005 – Oxidative stress is an important factor in many pathological conditions such as inflammation, cancer, ageing and organ response to ischemia‐reperfusion. Humans have developed a complex antioxidant system to eliminate or attenuate oxidative stress. Liver ischemia‐reperfusion injury occurs in a number of clinical settings, including liver surgery, transplantation, and hemorrhagic shock with subsequent fluid resuscitation, leading to significant morbidity and mortality.

25 August 2005