Percutaneous ablation procedures in cirrhotic patients with hepatocellular carcinoma submitted to liver transplantation: Assessment of efficacy at explant analysis and of safety for tumor recurrence

Maurizio Pompili, Vincenzo Giorgio Mirante, Gianfranco Rondinara, Luigi Rainero Fassati, Fabio Piscaglia, Salvatore Agnes, Marcello Covino, Matteo Ravaioli, Stefano Fagiuoli, Giovanni Gasbarrini, Gian Ludovico Rapaccini – 25 August 2005 – Aims of this retrospective study were to analyze the efficacy and safety of percutaneous ethanol injection (PEI) and radiofrequency ablation (RFA) in cirrhotic patients with hepatocellular carcinoma (HCC) submitted to orthotopic liver transplantation (OLT).

Hemodynamics and survival of patients with portopulmonary hypertension

Steven M. Kawut, Darren B. Taichman, Vivek N. Ahya, Sandra Kaplan, Christine L. Archer‐Chicko, Stephen E. Kimmel, Harold I. Palevsky – 25 August 2005 – It is not known whether patients with pulmonary arterial hypertension associated with portal hypertension (portopulmonary hypertension (PPHTN) have different disease characteristics from those of patients with other forms of pulmonary arterial hypertension.

The contemporary role of antioxidant therapy in attenuating liver ischemia‐reperfusion injury: A review

Georgios K. Glantzounis, Henryk J. Salacinski, Wenxuan Yang, Brian R. Davidson, Alexander M. Seifalian – 25 August 2005 – Oxidative stress is an important factor in many pathological conditions such as inflammation, cancer, ageing and organ response to ischemia‐reperfusion. Humans have developed a complex antioxidant system to eliminate or attenuate oxidative stress. Liver ischemia‐reperfusion injury occurs in a number of clinical settings, including liver surgery, transplantation, and hemorrhagic shock with subsequent fluid resuscitation, leading to significant morbidity and mortality.

Blood lactate but not serum phosphate levels can predict patient outcome in fulminant hepatic failure

Gerry C. MacQuillan, Moataz S. Seyam, Peter Nightingale, James M. Neuberger, Nicholas Murphy – 25 August 2005 – Early identification of those patients with fulminant hepatic liver failure (FHF) who need a transplant greatly helps in their management. A number of prognostic criteria have recently been proposed, including arterial blood lactate and serum phosphate concentrations. To validate their use, we retrospectively studied 83 consecutive patients with FHF admitted to our intensive treatment unit between August 2000 and March 2003.

Renal function after orthotopic liver transplantation is predicted by duration of pretransplantation creatinine elevation

Mical S. Campbell, David S. Kotlyar, Colleen M. Brensinger, James D. Lewis, Kirti Shetty, Roy D. Bloom, James F. Markmann, Kim M. Olthoff, Abraham Shaked, K. Rajender Reddy – 25 August 2005 – In patients with recent onset renal insufficiency, the decision to perform combined kidney/liver transplantation (CKLT) vs. orthotopic liver transplantation alone (OLTa) can be difficult. We hypothesized that duration of renal dysfunction may correlate with creatinine elevation after liver transplantation.

Nonmelanoma skin cancer after liver transplantation. Study of risk factors

J. Ignacio Herrero, Agustín España, Jorge Quiroga, Bruno Sangro, Fernando Pardo, Javier Alvárez‐Cienfuegos, Jesús Prieto – 25 August 2005 – Nonmelanoma skin cancer (NMSC) is a frequent complication after liver transplantation, but the risk factors of posttransplant NMSC have not been well defined. In a prospectively followed series of 170 liver transplant recipients, we assessed the incidence of NMSC, compared it with the expected incidence in the general population, and investigated which risk factors were related to NMSC.

Quality assurance, efficiency indicators and cost‐utility of the evaluation workup for liver transplantation

Paolo De Simone, Paola Carrai, Lidiana Baldoni, Stefania Petruccelli, Laura Coletti, Luca Morelli, Franco Filipponi – 25 August 2005 – We report the results of a retrospective review of the outpatient pretransplantation workup for United Network for Organ Sharing (UNOS) 3 patients adopted at a liver transplantation (LT) center and illustrate the efficiency indicators used for quality evaluation and cost‐analysis. A single‐center, pre‐LT evaluation workup was performed on an outpatient basis at a cost per patient evaluation of 2,770 Euros (€).

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