Jorge A. Marrero, Robert J. Fontana, Grace L. Su, Hari S. Conjeevaram, Anna S. Lok – 22 August 2005

Akira Anan, Gregory J. Gores – 22 August 2005

Hanh‐Tu Lieu, Frédéric Batteux, Marie‐Thérèse Simon, Alexandre Cortes, Carole Nicco, Flora Zavala, Alain Pauloin, José Guilherme Tralhao, Olivier Soubrane, Bernard Weill, Christian Bréchot, Laurence Christa – 22 August 2005 – Human hepatocarcinoma‐intestine‐pancreas/pancreatic‐associated protein HIP/PAP is a secreted C‐type lectin belonging to group VII, according to Drickamer's classification. HIP/PAP is overexpressed in liver carcinoma; however, its functional role remains unclear.

Ta‐Sen Yeh, Jeng‐Hwei Tseng, Tse‐Ching Chen, Nai‐Jen Liu, Cheng‐Tang Chiu, Yi‐Yin Jan, Miin‐Fu Chen – 22 August 2005 – A cohort of patients with intraductal growth‐type intrahepatic cholangiocarcinoma (IG‐ICC) and its precursor lesions, collectively termed intraductal papillary neoplasm of the liver (IPNL), was characterized with respect to demographics, clinical manifestations, perioperative management, long‐term survival, and molecular features associated with carcinogenesis.

Jean Pappas Molleston – 22 August 2005

Sharon J. Hutchinson, Sheila M. Bird, David J. Goldberg – 22 August 2005 – Quantitative estimates of the current and future burden of hepatitis C virus (HCV) disease are required to plan a public health response to the HCV epidemic with regard to both prevention and treatment. A forward projection model was used to estimate the numbers of both current and former injecting drug users (IDUs) who acquired HCV and progressed to moderate and severe disease in Glasgow and Scotland during 1960‐2030.

Jeffrey B. Schwimmer, Cynthia Behling, Robert Newbury, Reena Deutsch, Caroline Nievergelt, Nicholas J. Schork, Joel E. Lavine – 22 August 2005 – Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are common in children and adolescents. However, standard histological criteria for pediatric NAFLD and NASH are undeveloped. We reviewed consecutive patients ages 2 to 18 years with biopsy‐proven NAFLD diagnosed between 1997 and 2003. Biopsies were evaluated by two pathologists for individual features of steatohepatitis.

Ruben R. Plentz, Brigitte Schlegelberger, Peer Flemming, Michael Gebel, Hans Kreipe, Michael P. Manns, K. Lenhard Rudolph, Ludwig Wilkens – 22 August 2005 – Chromosomal instability (CIN) leads to an increase in aneuploidy and chromosomal aberrations in human hepatocellular carcinoma (HCC). Telomere shortening appears as one mechanism fostering the development of CIN. Whether telomere shortening correlates to specific genetic changes that characterize a certain type of cancer has yet to be established.

Timothy M. Pawlik, Eddie K. Abdalla, Melanie Thomas, Mark S. Roh, Gregory Y. Lauwers, Dario Ribero, Ronnie T. Poon, Jacques Belghiti, David M. Nagorney, Jean‐Nicolas Vauthey – 22 August 2005

Darius Moradpour, Volker Brass, Francois Penin – 22 August 2005 – Hepatitis C virus (HCV) is a human pathogen affecting nearly 3% of the world's population. Chronic infections can lead to cirrhosis and liver cancer. The RNA replication machine of HCV is a multi‐subunit membrane‐associated complex. The nonstructural protein NS5A is an active component of HCV replicase, as well as a pivotal regulator of replication and a modulator of cellular processes ranging from innate immunity to dysregulated cell growth.