Sharon J. Hutchinson, Sheila M. Bird, David J. Goldberg – 22 August 2005 – Quantitative estimates of the current and future burden of hepatitis C virus (HCV) disease are required to plan a public health response to the HCV epidemic with regard to both prevention and treatment. A forward projection model was used to estimate the numbers of both current and former injecting drug users (IDUs) who acquired HCV and progressed to moderate and severe disease in Glasgow and Scotland during 1960‐2030.

Jeffrey B. Schwimmer, Cynthia Behling, Robert Newbury, Reena Deutsch, Caroline Nievergelt, Nicholas J. Schork, Joel E. Lavine – 22 August 2005 – Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are common in children and adolescents. However, standard histological criteria for pediatric NAFLD and NASH are undeveloped. We reviewed consecutive patients ages 2 to 18 years with biopsy‐proven NAFLD diagnosed between 1997 and 2003. Biopsies were evaluated by two pathologists for individual features of steatohepatitis.

Ruben R. Plentz, Brigitte Schlegelberger, Peer Flemming, Michael Gebel, Hans Kreipe, Michael P. Manns, K. Lenhard Rudolph, Ludwig Wilkens – 22 August 2005 – Chromosomal instability (CIN) leads to an increase in aneuploidy and chromosomal aberrations in human hepatocellular carcinoma (HCC). Telomere shortening appears as one mechanism fostering the development of CIN. Whether telomere shortening correlates to specific genetic changes that characterize a certain type of cancer has yet to be established.

Timothy M. Pawlik, Eddie K. Abdalla, Melanie Thomas, Mark S. Roh, Gregory Y. Lauwers, Dario Ribero, Ronnie T. Poon, Jacques Belghiti, David M. Nagorney, Jean‐Nicolas Vauthey – 22 August 2005

Darius Moradpour, Volker Brass, Francois Penin – 22 August 2005 – Hepatitis C virus (HCV) is a human pathogen affecting nearly 3% of the world's population. Chronic infections can lead to cirrhosis and liver cancer. The RNA replication machine of HCV is a multi‐subunit membrane‐associated complex. The nonstructural protein NS5A is an active component of HCV replicase, as well as a pivotal regulator of replication and a modulator of cellular processes ranging from innate immunity to dysregulated cell growth.

Anna Glantz, Hanns‐Ulrich Marschall, Lars‐Åke Mattsson – 22 August 2005

Florence Wong – 22 August 2005

Frank A. Anania – 22 August 2005

Niels G. Venneman, Karel J. van Erpecum – 22 August 2005

Andres T. Blei – 22 August 2005