Transmission of T. cruzi infection via liver transplantation to a nonreactive recipient for Chagas' disease

Laura Barcán, Concepción Lunaó, Liliana Clara, Angel Sinagra, Alejandra Valledor, Ana María De Rissioí, Adrián Gadanoá, Myriam Martín García, Eduardo de Santibañes, Adelina Riarte – 25 August 2005 – Chagas' disease is an endemic zoonosis of South America caused by a protozoan parasite Trypanosoma cruzi. About 30% of infected people develop the disease. This disease is known to reactivate in immunocompromised hosts, such as patients with acquired immunodeficiency syndrome, leukemia, and transplantation.

Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases

Cosimo Colletta, Carlo Smirne, Carlo Fabris, Pierluigi Toniutto, Rachele Rapetti, Rosalba Minisini, Mario Pirisi – 24 August 2005 – The course of hepatitis C virus (HCV) infection carriers with normal/near‐normal aminotransferases (NALT) is usually mild; however, in a few, fibrosis progression occurs. We aimed to verify whether monitoring by liver biopsy might be replaced by noninvasive methods and to identify factors associated with fibrosis progression in patients with persistently normal alanine aminotransferases.

A genomic and proteomic study of the spectrum of nonalcoholic fatty liver disease

Zobair M. Younossi, Ancha Baranova, Katharine Ziegler, Luca Del Giacco, Karen Schlauch, Timothy L. Born, Hazem Elariny, Francesco Gorreta, Amy VanMeter, Abraham Younoszai, Janus P. Ong, Zachary Goodman, Vikas Chandhoke – 22 August 2005 – Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and some of its forms are progressive. This study describes the profiling of hepatic gene expression and serum protein content in patients with different subtypes of NAFLD.

HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice

Hanh‐Tu Lieu, Frédéric Batteux, Marie‐Thérèse Simon, Alexandre Cortes, Carole Nicco, Flora Zavala, Alain Pauloin, José Guilherme Tralhao, Olivier Soubrane, Bernard Weill, Christian Bréchot, Laurence Christa – 22 August 2005 – Human hepatocarcinoma‐intestine‐pancreas/pancreatic‐associated protein HIP/PAP is a secreted C‐type lectin belonging to group VII, according to Drickamer's classification. HIP/PAP is overexpressed in liver carcinoma; however, its functional role remains unclear.

Characterization of intrahepatic cholangiocarcinoma of the intraductal growth‐type and its precursor lesions

Ta‐Sen Yeh, Jeng‐Hwei Tseng, Tse‐Ching Chen, Nai‐Jen Liu, Cheng‐Tang Chiu, Yi‐Yin Jan, Miin‐Fu Chen – 22 August 2005 – A cohort of patients with intraductal growth‐type intrahepatic cholangiocarcinoma (IG‐ICC) and its precursor lesions, collectively termed intraductal papillary neoplasm of the liver (IPNL), was characterized with respect to demographics, clinical manifestations, perioperative management, long‐term survival, and molecular features associated with carcinogenesis.

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