Overcoming the portal steal phenomenon in auxiliary partial orthotopic liver transplantation by modulation of the venous outflow of the native liver

Dieter C. Broering, Jessica Walter, Atef F. Bassas – 25 August 2005 – The main drawback of auxiliary partial orthotopic liver transplantation (APOLT) is the competition of the portal flow between the graft and the native liver, leading to graft failure. In two patients with Crigler‐Najjar syndrome type I, the intrahepatic resistance of the native liver was increased by occluding the recipients middle hepatic vein during parenchymal transection, leading the portal flow towards the graft. This new surgical technique could encourage centers to recommence APOLT.

Emergency splenic arterial embolization for massive variceal bleeding in liver recipient with left‐sided portal hypertension

Hsin‐You Ou, Tung‐Liang Huang, Tai‐Yi Chen, Leo Leung‐Chit Tsang, Allan M. Concejero, Chao‐Long Chen, Yu‐Fan Cheng – 25 August 2005 – Splenic vein thrombosis with gastric variceal bleeding is difficult to manage, and splenectomy may be necessary to stop variceal bleeding. The authors report the case of a post–orthotopic liver transplant patient with bleeding gastric varices secondary to splenic vein thrombosis treated by partial splenic artery embolization.

Risk factors for Staphylococcus aureus infection in liver transplant recipients

Frédéric Bert, Claire Bellier, Ludovic Lassel, Valérie Lefranc, François Durand, Jacques Belghiti, France Mentré, Bruno Fantin – 25 August 2005 – Staphylococcus aureus is the leading cause of bacterial infection in liver transplant recipients. Preoperative nasal carriage of methicillin‐resistant S. aureus (MRSA) is associated with a high risk of infection. We conducted a retrospective cohort study in order to identify independent risk factors for early‐onset S. aureus infection after liver transplantation. Patients were screened preoperatively for methicillin‐susceptible S.

Transmission of T. cruzi infection via liver transplantation to a nonreactive recipient for Chagas' disease

Laura Barcán, Concepción Lunaó, Liliana Clara, Angel Sinagra, Alejandra Valledor, Ana María De Rissioí, Adrián Gadanoá, Myriam Martín García, Eduardo de Santibañes, Adelina Riarte – 25 August 2005 – Chagas' disease is an endemic zoonosis of South America caused by a protozoan parasite Trypanosoma cruzi. About 30% of infected people develop the disease. This disease is known to reactivate in immunocompromised hosts, such as patients with acquired immunodeficiency syndrome, leukemia, and transplantation.

Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases

Cosimo Colletta, Carlo Smirne, Carlo Fabris, Pierluigi Toniutto, Rachele Rapetti, Rosalba Minisini, Mario Pirisi – 24 August 2005 – The course of hepatitis C virus (HCV) infection carriers with normal/near‐normal aminotransferases (NALT) is usually mild; however, in a few, fibrosis progression occurs. We aimed to verify whether monitoring by liver biopsy might be replaced by noninvasive methods and to identify factors associated with fibrosis progression in patients with persistently normal alanine aminotransferases.

A genomic and proteomic study of the spectrum of nonalcoholic fatty liver disease

Zobair M. Younossi, Ancha Baranova, Katharine Ziegler, Luca Del Giacco, Karen Schlauch, Timothy L. Born, Hazem Elariny, Francesco Gorreta, Amy VanMeter, Abraham Younoszai, Janus P. Ong, Zachary Goodman, Vikas Chandhoke – 22 August 2005 – Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and some of its forms are progressive. This study describes the profiling of hepatic gene expression and serum protein content in patients with different subtypes of NAFLD.

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