Adenovirus‐mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo

Cho‐Rok Jung, Jinsang Yoo, Ye Jin Jang, Sangsoo Kim, In‐Sun Chu, Young Il Yeom, Jong Young Choi, Dong‐Soo Im – 20 April 2006 – The pituitary tumor transforming (PTTG) gene family comprises PTTG1, 2, and 3. Forced expression of PTTG1 (securin) induces cellular transformation and promotes tumor development in animal models. PTTG1 is overexpressed in various human cancers. However, the expression and pathogenic implications of the PTTG gene family in hepatocellular carcinoma are largely unknown.

Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction

Anabel Brandoni, Silvina R. Villar, Juan C. Picena, Naohiko Anzai, Hitoshi Endou, Adriana M. Torres – 20 April 2006 – Renal function in the course of obstructive jaundice has been the subject of great interest; however, little is known about the expression of renal organic anion transporters. The objective of this work was to study, in rats with acute extrahepatic cholestasis, the cortical renal expression of the organic anion transporter 1 (OAT1) and the organic anion transporter 3 (OAT3), in association with the pharmacokinetics and renal excretion of furosemide (FS).

Biliary complications following adult right lobe ex vivo split liver transplantation

Maciej Wojcicki, Michael A. Silva, Paras Jethwa, Bridget Gunson, Simon R. Bramhall, David Mayer, John A.C. Buckels, Darius F. Mirza – 20 April 2006 – Biliary complications are common following split liver transplantation (SLT). We analyzed the incidence, treatment, and outcome of biliary complications following adult right lobe ex vivo SLT performed between November 1992 and January 2005. There were 72 patients, of which 70 were analyzed. Early postoperative deaths resulted in 2 being excluded from the analysis. There were 44 males (median age, 48 yr; range, 19–70 yr).

Development of pulmonary hypertension in 5 patients after pediatric living‐donor liver transplantation: De novo or secondary?

Yasumasa Shirouzu, Mureo Kasahara, Yasutsugu Takada, Kaoru Taira, Seisuke Sakamoto, Kenji Uryuhara, Kohei Ogawa, Hiraku Doi, Hiroto Egawa, Koichi Tanaka – 20 April 2006 – The development of portopulmonary hypertension (PH) in a patient with end‐stage liver disease is related to high cardiac output and hyperdynamic circulation. However, PH following liver transplantation is not fully understood.

Subscribe to