Timothy M. Pawlik, Eddie K. Abdalla, Melanie Thomas, Mark S. Roh, Gregory Y. Lauwers, Dario Ribero, Ronnie T. Poon, Jacques Belghiti, David M. Nagorney, Jean‐Nicolas Vauthey – 22 August 2005

Ruben R. Plentz, Brigitte Schlegelberger, Peer Flemming, Michael Gebel, Hans Kreipe, Michael P. Manns, K. Lenhard Rudolph, Ludwig Wilkens – 22 August 2005 – Chromosomal instability (CIN) leads to an increase in aneuploidy and chromosomal aberrations in human hepatocellular carcinoma (HCC). Telomere shortening appears as one mechanism fostering the development of CIN. Whether telomere shortening correlates to specific genetic changes that characterize a certain type of cancer has yet to be established.

Jeffrey B. Schwimmer, Cynthia Behling, Robert Newbury, Reena Deutsch, Caroline Nievergelt, Nicholas J. Schork, Joel E. Lavine – 22 August 2005 – Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are common in children and adolescents. However, standard histological criteria for pediatric NAFLD and NASH are undeveloped. We reviewed consecutive patients ages 2 to 18 years with biopsy‐proven NAFLD diagnosed between 1997 and 2003. Biopsies were evaluated by two pathologists for individual features of steatohepatitis.

Sharon J. Hutchinson, Sheila M. Bird, David J. Goldberg – 22 August 2005 – Quantitative estimates of the current and future burden of hepatitis C virus (HCV) disease are required to plan a public health response to the HCV epidemic with regard to both prevention and treatment. A forward projection model was used to estimate the numbers of both current and former injecting drug users (IDUs) who acquired HCV and progressed to moderate and severe disease in Glasgow and Scotland during 1960‐2030.

Jean Pappas Molleston – 22 August 2005

Ta‐Sen Yeh, Jeng‐Hwei Tseng, Tse‐Ching Chen, Nai‐Jen Liu, Cheng‐Tang Chiu, Yi‐Yin Jan, Miin‐Fu Chen – 22 August 2005 – A cohort of patients with intraductal growth‐type intrahepatic cholangiocarcinoma (IG‐ICC) and its precursor lesions, collectively termed intraductal papillary neoplasm of the liver (IPNL), was characterized with respect to demographics, clinical manifestations, perioperative management, long‐term survival, and molecular features associated with carcinogenesis.

Hanh‐Tu Lieu, Frédéric Batteux, Marie‐Thérèse Simon, Alexandre Cortes, Carole Nicco, Flora Zavala, Alain Pauloin, José Guilherme Tralhao, Olivier Soubrane, Bernard Weill, Christian Bréchot, Laurence Christa – 22 August 2005 – Human hepatocarcinoma‐intestine‐pancreas/pancreatic‐associated protein HIP/PAP is a secreted C‐type lectin belonging to group VII, according to Drickamer's classification. HIP/PAP is overexpressed in liver carcinoma; however, its functional role remains unclear.

Akira Anan, Gregory J. Gores – 22 August 2005

Jorge A. Marrero, Robert J. Fontana, Grace L. Su, Hari S. Conjeevaram, Anna S. Lok – 22 August 2005

Zobair M. Younossi, Ancha Baranova, Katharine Ziegler, Luca Del Giacco, Karen Schlauch, Timothy L. Born, Hazem Elariny, Francesco Gorreta, Amy VanMeter, Abraham Younoszai, Janus P. Ong, Zachary Goodman, Vikas Chandhoke – 22 August 2005 – Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and some of its forms are progressive. This study describes the profiling of hepatic gene expression and serum protein content in patients with different subtypes of NAFLD.